Co-inhibitory receptors, transcription factors and tolerance Adel Mohammadzadeh, in International Immunopharmacology, 2020 1 Introduction T cells activation is a multistep process involving an interaction of T cell receptor (TCR)-complex with MHC-peptide and expression of co-stimulatory receptors along wi...
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871–882 (2011). This study establishes MYC-dependent regulation of glycolysis and glutaminolysis as being crucial for T cell activation and proliferation. Article CAS PubMed PubMed Central Google ...
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signals, a core group of transcription factors have essential roles in this pr
In addition, the transcription factors Myc and Hypoxia-inducible factor 1α (Hif1α – known to regulate cellular metabolism during hypoxia [24]) also seem to promote metabolic reprogramming after T cell activation [15]. Both tamoxifen-induced ablation of Myc as well as genetic-deletion of Hif...
2019 年 11 月 15 日,来自实验血液学国家重点实验室、中科院广州生物医药与健康研究院的王金勇团队联合蛋白质组学国家重点实验室、解放军总医院第五医学中心的刘兵团队在Cell Research上发表了题为《Guiding T lymphopoiesis from pluripotent...
Identification of a putative regulator of early T cell activation genes[J]. J Immunol,2010, 185(9):4972-4975. [2] Mognol GP,Carneiro FR,Robbs BK,et al. Cell cycle and apoptosis regulation by NFAT transcription factors :new roles for an old player[J]. Cell Death Dis,2016,7 :e2199....
英文名称:ELISA Kit for Linker For Activation Of T-Cell (LAT) 分子式:电询 纯度:99 % 产地:中国/美国/德国 品牌:BioLegend,Cygnus,IBL,TSZ等国内外品牌 包装规格:96T/48T 货号:XYA270Mu 别名:电询 小鼠T-细胞激活连接蛋白(LAT)检测试剂盒为小鼠T-细胞激活连接蛋白(LAT)的定量测定人血浆。ACTH免疫一二...
15.Chen W, Zhang L, Shao SX, Wang HP, Cui SJ, Zhang YN, et al. Transcription factors GATA4 and TBX5 promote cardiomyogenic differentiation of rat bone marrow mesenchymal stromal cells. Histol Histopathol (2015) ...
JNK is activated by MEKK1 through activation of MKK4 (mitogen-activated protein kinase kinase-4)/MKK7. These MAPKs directly phosphorylate transcription factors involved in the formation of the heterodimeric transcription factor, Jun-Fos complex, as well as NFAT and...
and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.储存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMed: PubMed...