CD4~+CD25~+ regulatory T cells inhibit organ-specific autoim- mune diseases induced by CD4~+CD25~- T cells and are potent suppressors of CD4~+CD25~- T cell activation in vitro. We dem- onstrate that CD4+CD25~+ T cells also suppress both prolifer- ation and IFN-#gamma# production by...
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We have, therefore, expanded our earlier work by using a panel of different T cell activation markers (CD25, CD26, CD40L, CD69). The study is based on 58 culprit lesions from patients who underwent coronary atherectomy. There were four groups of patients: chronic stable angina (n=13),...
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Indeed, the T cell activation marker CD25 was also reduced across conditions in the ascites, further supporting the contention that ascites is an immune-suppressive environment (Figure S6F). Consistent with the reduction in mitochondrial activity, expanded T cells cultured in ascites resulted in a ...
HER2-XPAT protein and unmasked HER2-TCE promoted similar T-cell activation in the tumor microenvironment (TME), indicated by increased expression of activation marker CD25 on both helper and cytotoxic T cells (Fig. 3c). T cells were not activated in peripheral blood where human HER2 is not ...
•从未接触的 CD4+ T 细胞亚群中阳性分离 CD25+ T 细胞。•用 DETACHaBEAD™ 从 CD4+ CD25+ Treg 细胞中去除磁珠。起始样品:PBMC 仅供科研使用。不可用于诊断程序。 规格 细胞类型T 细胞(调节性) 分离技术蛋白去除,然后进行阳性分离 池数量处理总计∼1x10^9个细胞...
cells after TCR-mediated stimulation from 24 to 120 h (Fig.5b, upper), and with each successive round of T cell proliferation, while CD25 was expressed similarly, independent of cell division (Fig.5b, lower). These results establish NME1 expression as a marker of T cell activation, ...
their designated functions, they must first be activated by complementary APC and co-stimulatory molecules. Naïve T cells differ phenotypically from activated effector cells by expressions of many surface receptors but are most commonly distinguished by the absence of the activation protein, CD25. ...
1c). This increase followed the expression of CD25, indicating naïve CD4+ T cells maintain zinc homeostasis in the time period following initial activation events. In the presence of IL-27, [Zn2+]i was increased by 4 days post activation (Fig. 1c) and after 6 days was significantly ...