在最近发表的Non-viral precision T cell receptor replacement for personalized cell therapy报道了个性化TCR-T细胞工程,利用CRISPR-Cas9技术去除了两条TCRα和TCRβ链,并采用非病毒方法同时插入了新抗原特异性TCR的序列,KI效率达到23%(范围为11.4%~46.8%),并在研究...
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell 186, 131–146 (2023). Article PubMed Google Scholar Chappert, P. et al. Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal...
胸腺上皮细胞(thymic epithelial cell,TEC)以及其他胸腺基质细胞分泌细胞因子, 如干细胞因子(stem cell factor,SCF)和白细胞介素 -7(interleukin-7,IL-7)等,并表达 Notch 配体 DLL4(Notch ligand delta-like ligand 4,DLL4) 以及主要组织相容性复...
Replacement of T cell function by a T cell product. Nat. New Biol. 237:15.Schimpl A, Wecker E (1972) Replacement of T-cell function by a T-cell product. Nature 237:15–17SCHIMPL, A. and WECKER, E. (1972). 'Replacement of T-cell function by a T-cell product.' Nature: New ...
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immuno
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Table S3. List of signature genes expressed in T cell clusters, related to Figures 2 and 5 Table S4. T cell receptor information of T cells, related to Figure 2 Table S6. List of signature genes expressed in non-exhausted non-reactive, exhausted reactive, and exhausted non-reactive CD4 +...
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2 Schemati c of nearby replacement 1. 3 算法的并行化 增加遗传 算法的多 样性能 提高算 法求解 的精 度.而并行算法能利用多机多核的计算资源运行多 个遗传算法, 可增加算法的随机多样性, 进而既可提 高遗传算法的优化效果, 又能加快算法的收敛速度. 为此, 本文将遗传算法进行了并行化, 即在 T SP ...
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, inc...