Elevated levels of anti-centromer antibodies, anti-topoisomerase I [anti-Scl-70] antibodies and the anti-RNA polymerase III antibodies, which belong to the group of ANA, are frequently present in the serum of patients suffering from systemic sclerosis and are therefore incorporated into the new ...
Lab Test (1) Tables (0) Videos (1) The cause of systemic sclerosis is unknown. Swelling of the fingers, intermittent coolness and blue discoloration of the fingers, joints freezing in permanent (usually flexed) positions (contractures), and damage to the gast...
Systemic recombinant human interferon-beta treatment of relapsing-remitting multiple sclerosis: pilot study analysis and six-year follow-up. A pilot study was undertaken to test the safety and establish the side effect profile of recombinant interferon-beta 1b (Betaseron, Berlex Laboratories, ...
Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events remains unknown. Given that SSc is a multifactorial disease caused by both genetic and environmental factors, we focus on the two transcription ...
Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens p
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 2
American Rheumatism Association (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma) Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheumatol 23:581–590 Article Google Scholar Tanimoto K, Nak...
Clinical course of atopic dermatitis in an adult with amyotrophic lateral sclerosis: aetiological implications of voluntary movements and dermatitis severity. Acta Derm Venereol. 2022;102:adv00644. https://doi.org/10.2340/actadv.v102.1121. Article PubMed Google Scholar Teodoro JS, Machado IF, ...
The performance characteristics of IIF assays and SPAs are disease-dependent; IIF assays are more sensitive than SPA for screening for systemic sclerosis (and systemic lupus erythematosus) but not Sjögren syndrome. For both IIF assays and SPAs, no single cut-off has both good sensitivity and go...
In conclusion, this modified murine model for drug-induced systemic inflammation and fibrosis uses a single procedure and provides reproducible skin and lung lesions, mimicking human systemic sclerosis (SSc) with ILD-like manifestation. Laboratory Investigation (2015) 95, 342–350; doi:10.1038/lab...