Spencer-Green G., Alter D., Welch H.G.: Test performance in systemic sclerosis: anti-centromere and anti-Scl-70 antibodies. Am. J. Med., 1997; 103: 242-248Spencer-Green G, Alter D, Welch HG. Test performance in systemic scle- rosis: anti-centromere and anti-Scl-70 antibodies. Am...
Systemic sclerosis, also known as scleroderma, is a rare connective tissue disorder with an unknown and complex pathogenesis. Scleroderma can be divided into 2 primary forms—localized scleroderma (including morphea, linear scleroderma, and scleroderma en coup de sabre) and systemic sclerosis. Systemic...
The assessment of disease activity in systemic sclerosis (SSc) is challenging owing to its heterogeneous manifestations across multiple organ systems, the variable rate of disease progression and regression, and the relative paucity of patients in early-phase therapeutic trials. Despite some recent succes...
Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients. Methods: A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were...
Over the years several lines of evidence have implied a pathological involvement of autonomic nervous system (ANS) in systemic sclerosis (SSc). However, the relationship between autonomic dysfunction and SSc is not yet fully understood. The aims of this scoping review were to map the research done...
Systemic sclerosis (SSC) orsclerodermais an autoimmune disorder of the connective tissue affecting the skin that is often associated with visceral involvement. It is characterized by excessive collagen deposition in the skin and internal organs, resulting in progressive tissuefibrosisand with changes in ...
An historical account of the study of progressive systemic sclerosis (diffuse scleroderma). Ann Intern Med. 1962;57(2_Part_1):305. https://doi.org/10.7326/0003-4819-57-2-305. Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee....
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals...
Systemic sclerosis (scleroderma; SSc) is an orphan disease with the highest case-specific mortality of any connective-tissue disease. Excessive collagen deposit in affected tissues is a key for the disease's pathogenesis and comprises most of the clinical manifestations. Lidocaine seems to be an alt...
ObjectiveTo construct a readily applicable formula for selecting patients with systemic sclerosis (SSc) for right-sided heart catheterization (RHC) based on the results of their pulmonary function tests (PFTs).MethodsThe diagnostic value of PFT variables was quantified in 386 patients with SSc against...