Summary Systemic sclerosis (SSc) is a rare condition in which the body''s own immune cells attack the skin making it thick and tight. The lungs and kidneys may also be damaged and up to half of severely affected patients die within 5 years. Standard treatment with immune‐suppressive drugs...
Rheumatic diseases are one of the main causes of physical disability of non-mental origin in the Western world according to the World Health Organization. Rheumatic diseases have a marked impact on the quality of life of patients. Among them, systemic sclerosis (SSc) has one of the highest mor...
Define Systemic sclerosis. Systemic sclerosis synonyms, Systemic sclerosis pronunciation, Systemic sclerosis translation, English dictionary definition of Systemic sclerosis. n. A pathological thickening and hardening of the skin. American Heritage® D
To investigate the clinical pattern, survival rate, causes of death and risk factors in a large cohort of Chinese Han patients with systemic sclerosis (SSc). Inpatients treated from 2002 to 2014 were included in this study. Patients were classified into diffuse cutaneous SSc (dcSSc), limited cu...
systemic sclerosis, treatment primarily focuses on managing affected organs and alleviating symptoms to prevent further organ damage in individuals with systemic sclerosis. This activity addresses the presentation, evaluation, and management of systemic sclerosis and examines the role of an interprofessional ...
Systemic sclerosis and scleroderma Systemic sclerosis/scleroderma is an autoimmune disease clinically characterized byfibrosisand vascular abnormalities affecting the skin, joints, and internal organs (above all the esophagus, and thelower gastrointestinal tract, as well as the lungs, the heart, and the ...
We conducted followup of 264 patients with definite systemic sclerosis (SSc) who were entered into the multicenter Scleroderma Criteria Cooperative Study (SCCS) during 1973-1977. At the end of the study (average 5.2 years of followup), 38% were known to be alive, 50% were dead (68% of ...
The cause of systemic sclerosis is not known, but it is thought to be an autoimmune disorder. In anautoimmune disorder, antibodies or cells produced by the body attack the body’s own tissues. This disease is more common among women and most common among people...
Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis. 2007;66(7):940-4. Adler S et al. Systemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group. Arthritis Res Ther. 2018;...
The assessment of disease activity in systemic sclerosis (SSc) is challenging owing to its heterogeneous manifestations across multiple organ systems, the variable rate of disease progression and regression, and the relative paucity of patients in early-phase therapeutic trials. Despite some recent succes...