胱氨酸/谷氨酸反向转运蛋白(System xc-)系统位于细胞膜上,以1:1的比例用胞内谷氨酸来换取胞外的胱氨酸 (Cys2),胱氨酸在谷氨酸半胱氨酸连接酶 (GCL) 和谷胱甘肽合成酶 (GSS) 的催化作用下合成谷胱甘肽 (GSH)。谷胱甘肽过氧化物酶(GPX4) 可将细胞毒性脂质过氧化物 (L-OOH) 还原为相应的醇 (L-OH),当抑制GP...
铁死亡机制 我们可以对铁死亡进行一个总结(如下图):下面部分首先system xc-使胱氨酸进入胞内,胱氨酸还原为半胱氨酸,半胱氨酸和谷氨酸合成还原型谷胱甘肽,谷胱甘肽被GPX4用于将PUFA磷脂氢过氧化物(PUFA-PL-OOH)还原成非致命性PUFA磷脂醇(PUFA-PL-OH)。或者,iPLA2β将磷脂上的氧化PUFA-OOH尾巴切除抑制铁死亡。上面部...
Bortezomib resistance in MM cells is linked to elevated expression of xCT (the subunit of system Xc ). Extracellular glutamate released by system Xc can bind to glutamate metabotropic receptor (GRM) 3, thereby upregulating Rab27-dependent vesicular trafficking. Since Rab27 is also involved in ...
How does targeting system Xc − in both Myeloma cells and Bone Marrow Stromal Cells (BMSCs) enhance the anti-myeloma effect of Bortezomib? What correlation was found between the expression of certain proteins and the survival of Myeloma patients in the Myeloma Research Foundation (MMRF) cohort?
System xc‐ is Localized to Early Endosomes which Facilitates Regulated Membrane Trafficking 来自 Semantic Scholar 喜欢 0 阅读量: 59 作者:A Goltz,M Wixson,LA Chase 摘要: The membrane transporter, System x c , catalyzes the exchange of cystine and glutamate across the membrane of many cell types...
Bwjl08ec feeder KCT five axis tomogr Five axis X-ray syst Two axis tomography Two axis X-ray syste X-ray system XC 805 FPC / glue sprayer, COUGAR EVO Cheetah EVO Board splitter m-330 Board splitter M-300 Sun series temperatu Lighting II series t ...
配套使用/相关产品 Xilinx FPGA,CPLDS,Platform Flash PROM,XC18V0 可售卖地 全国 型号 HW-FLYLEADS 技术参数 品牌: XILINX/赛灵思 型号: HW-FLYLEADS 封装: BGA 批号: 最新批次 数量: 150 制造商: Xilinx Inc. 配件类型: 并行缆线 配套使用/相关产品: Xilinx FPGA,CPLDS,Platform Flash PROM,XC18V00...
The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc− of
We have shown that in ovarian cancer cells under oxidative stress, xCT expression and the function of system xc− increase to maintain levels of GSH [15]. In addition, we determined that various cancer cell lines, including human and mouse breast cancer and mouse melanoma cells, express high...
Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β JA, Hewett SJ (2010) Regulation of system x(c)(-) activity and expression in astrocytes by interleukin- 1β: implications for hypoxic neuronal injury... Nicole,A.,Jackman,... - 《Glia》 被引量: 40发表: ...