system xc-广泛分布在磷脂双层中。它是细胞中重要抗氧化系统的一部分,是由SLC7A11和SLC3A2两个亚基组成的异二聚体。胱氨酸和谷氨酸通过系统Xc-以1:1的比例交换进出细胞,被吸收的胱氨酸在细胞中还原为半胱氨酸,其参与GSH的合成。GSH在谷胱甘肽过氧化物酶(GPXs)的作用下降低ROS。抑制system xc-的活性通过抑制胱氨...
胱氨酸/谷氨酸反向转运蛋白(System xc-)系统位于细胞膜上,以1:1的比例用胞内谷氨酸来换取胞外的胱氨酸 (Cys2),胱氨酸在谷氨酸半胱氨酸连接酶 (GCL) 和谷胱甘肽合成酶 (GSS) 的催化作用下合成谷胱甘肽 (GSH)。谷胱甘肽过氧化物酶(GPX4) 可将细胞毒性脂质过氧化物 (L-OOH) 还原为相应的醇 (L-OH),当抑制GP...
基于System Xc-/GPX4通路探讨白术内酯I对2型糖尿病大鼠胰岛细胞铁死亡的作用机制 全球糖尿病的患病率及死亡率正迅速上升,据国际糖尿病联盟的最新数据显示,预计到2045年,全球糖尿病患病人数将达7.832亿,其中2型糖尿病(type 2 diabetes mel...
System xc− is a glutamate/cystine exchanger, formed by a catalytic subunit called xCT and a regulatory subunit 4F2hc, whose activity is crucial to the synthesis of glutathione, which is a key antioxidant molecule for cells. Although some studies have shown that glutamate transport mediated by...
System xc‐ is Localized to Early Endosomes which Facilitates Regulated Membrane Trafficking 来自 Semantic Scholar 喜欢 0 阅读量: 57 作者:A Goltz,M Wixson,LA Chase 摘要: The membrane transporter, System x c , catalyzes the exchange of cystine and glutamate across the membrane of many cell types...
System xc−belongs to the SoLute Carrier 7 (SLC7) family of secondary active amino acid transporters and is a heterodimer, composed of a light chain (also called xCT or SLC7A11) and a heavy chain 4F2hc. The heavy chain 4F2hc is a single transmembrane spanning glycoprotein (also called...
System Xc− Glutamate Exosome Multiple myeloma Bone marrow Abbreviations BM Bone marrow BMMC Bone marrow mononuclear cell BMSC Bone marrow stromal cell BZ Bortezomib CM Conditioned medium CPPG (RS)-α-Cyclopropyl-4-phosphonophenylglycine DR Drug resistance EFS Event-free survival EX Exosome FDA US ...
配套使用/相关产品 Xilinx FPGA,CPLDS,Platform Flash PROM,XC18V0 可售卖地 全国 型号 HW-FLYLEADS 技术参数 品牌: XILINX/赛灵思 型号: HW-FLYLEADS 封装: BGA 批号: 最新批次 数量: 150 制造商: Xilinx Inc. 配件类型: 并行缆线 配套使用/相关产品: Xilinx FPGA,CPLDS,Platform Flash PROM,XC18V00...
The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc− of
System xc- 是一种逆向转运蛋白,负责将胱氨酸(cystine)输入哺乳动物细胞,这是合成谷胱甘肽 (GSH) 所必需的,GSH是抑制铁死亡的脂质氢过氧化物酶 GPX4 的辅助因子。RSL3(RAS-selective lethal 3)和 erastin(eradicator of RAS and small T (ST) antigen-expressing cells)通常用于抑制模型系统中的 GSH 过氧化物酶...