Coupled transcription and translation processes in bacteria cause indiscriminate translation of intact and truncated messenger RNAs, inevitably generating nonfunctional polypeptides. Here, we devised a synthetic protein quality control (ProQC) system tha
Linear regression model is like drawing a straight line through a scatterplot of data points. It’s useful for forecasting property values depending on characteristics such as square footage and location. 04. Decision trees AI model For AI, decision trees are similar to flowcharts. They make dec...
The synthetic control method (SCM) is a popular approach for estimating the impact of a treatment on a single unit in panel data settings. The "synthetic control" is a weighted average of control units that balances the treated unit's pre-treatment outcomes and other covariates as closely as...
The complete hidden state is used during data synthesis as a way of accounting for historical events. The output layers are a set of linear transformations that take as input the concatenation of the output of the LSTM and the embedded baseline characteristics. These output layers make the ...
The solid line is the linear regression line for the negative control (single KO) pgRNAs, while dashed lines indicate ± 2 residuals. (B) CRISPR scores for representative synthetic lethal paralog pairs. Data shown are the mean CRISPR score for each single KO or DKO target across three ...
Bank transactions are highly confidential. As a result, there are no real public data sets that can be used to investigate and compare anti-money laundering (AML) methods in banks. This severely limits research on important AML problems such as efficienc
The output layers are a set of linear transformations that take as input the concatenation of the output of the LSTM and the embedded baseline characteristics. These output layers make the predictions for the next time points generated by the LSTM conditioned on the baseline characteristics. ...
The foundational pieces emerging, in the form of standardized DNA parts, packaged for combinatoric assembly using standards such as BioBricks. But: Creating new DNA parts is tedious and time-consuming Constructing systems from sets of DNA parts is an ad hoc, manual process that limits the size...
Researchers, policy-makers, and industry practitioners alike herald the Knowledge-Based Bio-Economy (KBBE) as the “Next Big Thing” in societal progress. The story, which receives a lot of attention, goes like this: Over the last decades, economies around the globe have transformed into a Kn...
As halide ions are excellent leaving groups in the SN2 reactions, we initially tried to use haloacetic acids as reactants to react with 2 to generate glyphosate (Fig. 8a and Table 2). In this approach, we had to control a 1: 1 ratio of 2 to haloacetic acids to prevent the formation...