Ursodeoxycholic acidBisnoralcoholSynthesisA novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were ...
Bandiera et al., A Convenient Procedure for the Synthesis of Ursodeoxycholic Acid Sulfated Derivates, Synthetic Communications, vol. 17, No. 9, 1987, pp. 1111 1117.BANDIERA T ET AL: " A CONVENIENT PROCEDURE FOR THE SYNTHESIS OF URSODEOXYCHOLIC ACID SULFATED DERIVATIVES " SYNTHETIC COMMUNICATIONS,...
Engineering regioselectivity of a P450 monooxygenase enables the synthesis of ursodeoxycholic acid via 7β-hydroxylation of lithocholic acid. Angew. Chem. Int. Ed. 60, 753–757 (2021). Article CAS Google Scholar Bokel, A., Hutter, M. C. & Urlacher, V. B. Molecular evolution of a ...
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo-and regioselective 7β-hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydroxylate testosterone at the 7β-position but LCA is ...
T. Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution. Nat. Chem. 3, 738 (2011). Article CAS PubMed Google Scholar Grobe, S. et al. Engineering regioselectivity of a P450 monooxygenase enables the synthesis of ursodeoxycholic acid via 7β...
rising to 15 ℃ for another 20 min in the step of forming mixed anhydride,and 1.5 mol/L NaOH was used to dissolve taurine before aminolysis,and crude product was recrystalled by acetone in purifying process.According to the conditions described,taurohyodeoxycholic acid yields 49% with mass ...
摘要: A process for the production of disubstituted bile acid analogs, including the disubstituted analogs of such bile acids as, lithocholic, hyodeoxycholic, cholic, chenodeoxycholic and ursodeoxycholic acids.DOI: US4545938 A 被引量: 35 年份: 1990 ...
Hydroxysteroid dehydrogenases have been used to carry out the selective oxidoreduction of both steroidic and non-steroidic compounds. For example, precursors of chenodeoxycholic acid and ursodeoxycholic acid, drugs widely employed for the dissolution of cholesterol gall stones, have been prepared in high...
Though ursodeoxycholic acid (UDCA) remains the baseline treatment for most cholestatic liver diseases, UDCA treatment leaves approximately one-third of pat... M Wagner,P Fickert - 《Annual Review of Pharmacology》 被引量: 0发表: 2020年 Using solution containing nitric oxide synthase for synthesis ...
Among the metabolites examined, primary bile acids, particularly chenodeoxycholic acid, CA, and murine-specific primary bile acids (α-MCA and β-MCA), as well as the secondary bile acid ursodeoxycholic acid, were significantly upregulated in the LOW group mice (Figure 3c). Bile acids are ...