Scott A. LanemanDSM Pharm. Chem., Inc., Greenville, NC 27834, USAJohn Wiley & Sons, Ltd.cheminformAger DJ, Laneman SA (2004) Synthesis of unnatural amino acids. In: Blaser HU, Schmidt E (eds) Asymmetric catalysis on industrial scale. Wiley, Weinheim, p 259...
Highly substituted unnatural ?-amino esters, for example, ethyl 3-alkyl-4-(aryl or vinyl)-2-( N-4-methoxyphenyl?amine)pent-4-enoates were prepared in a regiocontrolled and diastereoselective manner via Pd(II)-catalyzed three-component coupling of boronic acids and allenes with ethyl imino...
Agrobiol., Univ. Stud. “La Tuscia”, I‐01100 Viterbo, ItalyJohn Wiley & Sons, LtdChemInformSaladino R, et al. A new and efficient synthesis of unnatural amino acids and peptides by selective 3,3-dimethyldioxirane side chain oxidation. J. Org. Chem. 1999; 64:8468-8474....
LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides Jun-Liang Zhou, Yun-Qi Liu & Zhan-Kui Sun Sci. China Chem., 2023, 66(6): 1788–1794 Triazole backbone ligand in an unprece...
Subsequently, we shifted our attention to the scope of Katritzky salts for the synthesis of unnatural α-amino acids using a series of secondary alkyl substituted pyridinium (Fig.2b). Uniformly good yields were obtained (7a–7h, up to 92%). Importantly, this reaction could be extended to glyc...
Herein, we disclose an expedient visible-light-mediated, organophotoredox-catalyzed multicomponent synthesis of unnatural amino acids using a Katritzky salt, glyoxal derivatives, and substituted anilines. Mechanistically, an alkyl radical is generated from the Katritzky salt via a deaminative process that...
S. Evaluation of catalyst acidity and substrate electronic effects in a hydrogen bond-catalyzed enantioselective reaction. J. Org. Chem. 75, 7194–7201 (2010). Article CAS Google Scholar Lang, K. & Chin, J. W. Cellular incorporation of unnatural amino acids and bioorthogonal labeling of ...
CHAPTER 12:Catalytic C–H/C–X Bond Functionalisation of Nucleosides, Nucleotides, Nucleic Acids, Amino Acids, Peptides and Proteins Pd‐catalysed cross‐coupling chemistry is widely used to access modified and unnatural derivatives of nucleosides, nucleotides and amino acids. Many biologically active...
Fluorescent unnatural amino acids (UAAs), when genetically incorporated into proteins, can provide unique advantages for imaging biological processes in vivo. Synthesis of optically pure L-enantiomer of fluorescent UAAs is crucial for their effective application in live cells. An efficient six-step synt...
ChemInform Abstract: Synthesis of Unnatural Amino Acid Derivatives via Palladium-Catalyzed 1,4-Addition of Boronic Acidsaminocarboxylic acids (hydrazinocarboxylic acids) and esters (benzene compounds)addition reactionsas possible inhibitors of protein—protein interactionsdoi:10.1002/chin.201033075...