Plants and microorganisms can synthesize amino acids from simple nitrogen compounds such as nitrate or ammonia, or from those released during protein turnover. Animals cannot form amino acids from inorganic nitrogen compounds, but obtain them from protein in the diet or from the breakdown of body ...
Metal-catalysed reactions involving ammonia gas are plagued by ammonia’s strong Lewis basicity, which leads to poor chemoselectivity and enantioselectivity. Here we introduce a strategy for preparing chiral α-amino acids directly from ammonia. By the c
lipoate metabolism and protein lipoylation required for the operation of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete glucose oxidation with an exit of acetyl-CoA and α-ketoglutarate from the TCA cycle to the syntheses of amino acids, such as arginine and ...
When the compound of formula II is an alcohol or a thioalcohol, the reaction is carried out in the presence of a Lewis acid (e.g. BF3). The N-protecting group is a conventional amino acid-protecting group, and its removal can be achieved, e.g. in the case of BOC group, by ...
Fluorescent D-amino acids (FDAAs) are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation. Here we provide a protocol for the synthesis of four FDAAs...
Stereoselective synthesis of α,γ-diamino-β-hydroxy amino acid esters: A new class of amino acids Isocyano-acetic acid ethylester 3 undergoes a base catalyzed aldol-type addition to N,N-dibenzylamino aldehydes 6 to form oxazolines 7 stereoselectively; t... MT Reetz,T Wuensch,K Harms - ...
The synthesis of enantiomerically pure non-proteinogenic bis and cyclic amino acids 3a,b and achiral amino acid 3c using chiral Ni II complex 1 and α,α′-dibromo- o-xylene as a bifunctional agent of alkylation is presented. 关键词: amino acids, peptides diastereoselective syntheses, enantiosel...
HIGHLIGHTSModular synthesis of β-amino acids from alkenes, amines, and CO2viaphotoredox/copper dual catalysisLei Song & Jie WuSci. China Chem., 2023, https://doi.org/10.1007/s11426-023-1848-9REVIEWSPhotoinduced difunctionaliz...
Synthesis of amino acid-derived imidazoles from enantiopure N-protected α-amino glyoxals A range of novel imidazoles, including three histidine derivatives, with chiral side chains derived from amino acids and dipeptides have been synthesised f... Michelle Groarke and M.Anthony McKervey and Mark ...
acids into highly valuable non-racemic chiral α-amino acids bearing unnatural side chains, which are sought-after synthetic building blocks due to their modulated chemical, physical and pharmaceutical properties13,14,15,16,17,18(Fig.1c). Direct α-amination of carboxylic acids has rare precedents...