The rate and molecular spectrum of mutation are selectively maintained in yeast Article Open access 30 June 2021 Loss-of-function mutations are main drivers of adaptations during short-term evolution Article Open access 26 March 2024 Changes in the distribution of fitness effects and adaptive ...
1 Model performance in recovering driver mutation rates in simulations. (a) Our method is able to recover driver mutation rates accurately across a range of mutation rates (5 × 105 simulation runs were performed). At higher driver mutation rate, it is mainly limited by clonal interference...
This has implications for the application of synonymous divergence in estimating the mutation rate.doi:10.1186/gb-2005-6-9-r75JV ChamaryLaurence D HurstGenome BiologyChamary, J.V., and Hurst, L.D. (2005). Evidence for selection on synonymous mutations affecting stability of mRNA secondary ...
(AIDS) in humans. Because the virus rapidly and constantly evolves, at the moment there is no cure nor vaccine against HIV infection. The HIV virus presents a very high mutation rate that allows it to evade the response of our immune system as well as the action of specific drugs. At ...
[21,163]. In addition, generation of robust prediction tools is highly dependent on the availability of disease-associated genetic data that can be used to train ML systems. Numerous data sets have been curated with information on disease-related variants, such as Human Gene mutation database (...
Therefore, a mutation that changes the DNA sequence of a gene won’t necessarily change the sequence of the encoded protein if the mutation results in a “synonymous codon.” To make a protein, DNA in the nucleus of a cell is first transcribed into a messengerRNA(mRNA). The mRNA is then...
[21,163]. In addition, generation of robust prediction tools is highly dependent on the availability of disease-associated genetic data that can be used to train ML systems. Numerous data sets have been curated with information on disease-related variants, such as Human Gene mutation database (...
As expected, the synonymous mutation rate was lower than the total mutation rate (Fig. 1a, top). We observed that the synonymous mutation frequen- cies vary widely across patients and histology indications. Across the indications, Skin- Melanoma has the highest median synonymous mutation ...
Determinants of Substitution Rates in Mammalian Genes: Expression Pattern Affects Selection Intensity but Not Mutation Rate To determine whether gene expression patterns affect mutation rates and/or selection intensity in mammalian genes, we studied the relationships between sub... D Laurent,M Dominique ...
in those species for which the point mutation rate depends strongly on the sequence context of a nucleotide — for example, in mammals, which experience hyper- mutable CpG dinucleotides — the mutational model predicts a strong context dependence of codon usage, which has indeed been observed12. ...