Substitution rate heterogeneity and the male mutation bias. J. Mol. Evol. 62:226-233.Berlin S, et al. 2006. Substitution rate heterogeneity and the male muta- tion bias. J Mol Evol. 62:226-233.Berlin S, Brandstro¨m M, Backstro¨m N, Axelsson E, Smith NGC, Ellegren H. ...
Plausible rates of mutation innatural populationscan be extrapolated from laboratory experiments which measure the time-dependent and cell-division-dependent rates of nucleotide substitution[33]. Althoughmutation ratesin natural environments are assumed to be similar to those seen in laboratory environments,...
What is the difference between mutation rate and substitution rate? What is a mutation and why is it important to evolution? What is synonymous mutation? What is the main factor determining how much change in a protein is caused by a frameshift mutation?
. The rate of spontaneous mutation in the wild-type MFIG001 strain to voriconazole was 2.78 × 10−10(±6.9 × 10−11) per spore, similar to rates measured in other fungal species40,41,42. The modified Luria–Delbrück method was validated by treatments with the mutagen ethyl...
"The rate and pattern of sequence substitutions in the mitochondrial DNA (mtDNA) control region (CR) is of central importance to studies of human evolution and to forensic identity testing. Here, we report a direct measurement of the intergenerational substitution rate in the human CR. We compare...
mutation rates. These positions may manifest as mutational hotspots, which are recurrently mutated across cancer patients. Here, we use mutational hotspots identified across 2583 whole cancer genomes to discover and characterize localized mutational processes, including their mutation rate and sequence ...
Whole genome sequencing (WGS) studies have estimated the human germline mutation rate per basepair per generation (~1.2 × 10−8) to be higher than in mice (3.5–5.4 × 10−9). In humans, most germline mutations are paternal in origin and numbers of mutations per offspring ...
The rate of this increase as well as the spectrum of mutations (basepair substitutions, deletions, translocations) differed greatly from organ to organ. For example, while in the intestine point mutations accumulated rapidly to a very high level at old age, in heart and liver also the ...
As humans left Africa they lost variability, which, if HI operates, should have reduced the mutation rate in non-Africans. Relative substitution rates were quantified in diverse humans using aligned whole genome sequences from the 1,000 genomes project. Substitution rate is consistently greater in ...
We observed a false- discovery rate (FDR) of 29% which represents the per- centage of somatic mutations called from RNA-seq not having evidence in the corresponding DNA exome-seq sample (Fig. 1d, Additional file 1: Figure S1c; see the "Methods" section). Mutations with a higher ...