family of proteins, as it executes two distinct, Ca2+-independent, functions in intracellular membrane trafficking that have no precedent in this protein family. A relatively small number of synaptotagmin isoforms (chiefly syt-1 and syt-7) have been the focus of intense study, and that body of...
The synaptotagmin family of vesicle proteins is believed to mediate calcium-dependent regulation of membrane trafficking. Detailed biochemical and in vivo studies of the most characterized isoform, synaptotagmin 1 (syt 1), have provided compelling evidence that it functions as a calcium sensor for fast...
3 Localization of active zone proteins using structured-illumination microscopy. a) Representative fluorescence images of a calyx of Held from a WT mouse, immunolabeld using primary antibodies against Bassoon, followed by multiple secondaries with different fluorophores. To ensure proper SIM microscope ...
Synaptotagmin-1 is one of the main proteins located in the synaptic vesicle membrane (Zhou et al., 2017). As shown in the present study, hippocampal synaptotagmin-1 levels were decreased after chronic stress, consistent with a previous report showing that synaptotagmin-1 levels were decreased in...
associationbetweendifferentSVproteins.Wedemonstratethatendocyticsortingofthecalciumsensorsynaptotagmin1(Syt1)ismediatedbytheoverlappingactivitiesoftheSyt1-associatedSVglycoproteinSV2A/BandtheendocyticSyt1-adaptorstonin2(Stn2).DeletionorknockdownofeitherSV2A/BorStn2resultsinpartialSyt1lossandmissortingofSyt1tothe...
Given mutations in the SYT family cause disorders in both the central and peripheral nervous system in humans, ongoing efforts are defining how these proteins regulate vesicle trafficking within distinct neuronal compartments. Here, we review the Drosophila SYT family and examine their role in synaptic...
R. Cell signalling diversity of the Gqα family of heterotrimeric G proteins. Cell Signal 18, 135–150 (2006). Article CAS PubMed Google Scholar Atwood, B. K., Lopez, J., Wager-Miller, J., Mackie, K. & Straiker, A. Expression of G protein-coupled receptors and related proteins ...
The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca2+-triggered release remain unknown. A subset of the synaptotagmin (syt) family of protein