A new mechanism by which glial cells stimulate neurite outgrowth has recently been discovered in olfactory ensheathing glia [64]. This special type of glial cell in the olfactory bulb guides and promotes the growth of axons from olfactory receptor neurons, which are generated throughout life and i...
Recent research has uncovered several examples connecting autophagy and hormonal-type regulations interacting between organ systems in non-cell autonomous regimes. For instance, Atg18 acts non-cell autonomously both in neurons and in intestines to firstly, maintain the wild-type lifespan of C.elegans ...
(A) Representative fluorescent images from RNAScope in situ hybridization analysis from Organ of Corti sections. Top: Nlgn1 (green); Bottom: Nlgn3 (green), expression was undetectable in cells positive for Myo7a (red) and Tubb3 (blue). (B) Representative fluorescent images from RNAScope in ...
(D) Quantification of BrdU/TH double-positive cells within CB sections of animals exposed to hypoxia (Hx), with or without bosentan (B), illustrating how blocking of endothelin receptors prevents hypoxia-induced activation of neural cell proliferation in the organ (n = 5 CBs for each condition...
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A 58-year-old man visited an orthopedic clinic complaining of pain in his right lower back and numbness in his lower limbs for one month. Imaging tests revealed a tumorous lesion from the left side of the second lumbar vertebra to the paraspinal muscles. CT-guided biopsy of the tumor was ...
Multiple myeloma (MM) is a heterogenous plasma cell malignancy characterized by clonal proliferation of plasma cells and organ damage. Autologous transplantation with high dose chemotherapy is the standard of care in frontline treatment of eligible patients with MM. ...
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(MM cells) that crowd out healthy blood cells in the bone marrow, infiltrate other tissues and cause potentially life-threatening organ injury. Despite treatment advances, MM is not curable and while current treatments are able to slow the progression of the cancer, most patients will ultimately ...