Case report Mitochondrial diseases show a broad phenotypic spectrum and are underdiagnosed. We present a 37-year-old woman referred to our neurology clinic after an incidental finding of bilateral caudate, lentiform and pulvinar calcification during workup for cochlear implant surgery. She was born at...
Review of the literature on major mental disorders in adult patients with mitochondrial diseases. Mitochondria are intracellular organelles crucial to the production cellular energy. Mitochondrial disease results from a malfunction in this biochemical c... O Fattal,K Budur,AJ Vaughan,... - 《Psychosoma...
there are antibody tests for most of the different types of viral hepatitis and immunological tests forprimary biliary cirrhosis(antimitochondrial antibodies) or chronic autoimmune hepatitis(smooth muscle antibody). Additionally, there are special tests forhemochromatosis(iron-related tests), Wilson...
TEFMvariants impair mitochondrial transcription causing childhood-onset neurological disease Van Hauteet aldescribe autosomal recessive TEFM variants that impair mitochondrial transcription elongation and reduce the levels of promoter distal mitochondrial RNA transcripts, leading to heterogeneous mitochondrial diseases...
SARS-CoV-2 and mitochondrial proteins in neural-derived exosomes of COVID-19. Ann Neurol. 2022;91(6):772-781. doi:10.1002/ana.26350PubMedGoogle ScholarCrossref 25. Badran Z, Gaudin A, Struillou X, Amador G, Soueidan A. Periodontal pockets: a potential reservoir...
The mitochondria are the battery packs of the cell and they are extremely important. High levels of oxidative stress wear down the mitochondria and cause a dysfunctional state. Studies have found that individuals with Alzheimer’s disease have an advanced state of mitochondrial dysfunction (28,29)....
Multiple sclerosis is a disease that causes demyelination of the brain and spinal cord nerve cells. When this occurs, axons (the parts of the nerve cells that conduct impulses to other cells), don't work as well. Myelin acts as insulation on electrical wires. As more areas or nerves are ...
Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to have key roles1,2. An early-onset form of Parkinson’s disease is associated with mutations in the PINK1 kinase and PRKN ubiquitin ligase genes3. PINK1 and ...
Imbalances in NAD+ homeostasis have been linked to aging and various diseases. Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remai
19 Thus, our study both expands the medical indication of RBA, and supports a way to treat the secondary disease in RA. Nonetheless, how the rebalancing of macrophages affects the number of osteoclasts and osteoblasts remains to be explored. In conclusion, we constructed a self-assembled nano...