Case report Mitochondrial diseases show a broad phenotypic spectrum and are underdiagnosed. We present a 37-year-old woman referred to our neurology clinic after an incidental finding of bilateral caudate, lentiform and pulvinar calcification during workup for cochlear implant surgery. She was born at...
Figure 2. Distribution of Core Symptom Severity Scores Over Time in Adults With Postacute Sequelae of SARS-CoV-2 Infection View LargeDownload Dashed line on the left marks the end of the 15-day treatment period, and on the right, it marks the 10-week primary end point. NMV/r indicates ...
Cyclothymic disorder is characterized by at least two years in adults, or one year in children and adolescents, of episodes of having symptoms of depression and episodes of hypomanicsymptoms that do not qualify for having either a full major depressive, manic, or hypomanic episode. Mixed features...
TEFMvariants impair mitochondrial transcription causing childhood-onset neurological disease Van Hauteet aldescribe autosomal recessive TEFM variants that impair mitochondrial transcription elongation and reduce the levels of promoter distal mitochondrial RNA transcripts, leading to heterogeneous mitochondrial diseases...
The most common allergens in adults are peanuts, tree nuts, and shellfish. Gluten is not a common food allergy, and true gluten hypersensitivity, or celiac disease, is mediated by another type of antibody (not IgE but IgA) and also leads to different symptoms (including chronic abdominal ...
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate th
expression profile of SARS-CoV-2 receptors in the different cell types of the CNS and the possible role of aging in the neurological outcomes of COVID-19. A special emphasis will be placed on mitochondrial functions because dysfunctional mitochondria are also a strong inducer of inflammatory ...
hippocampus (HIP) of the adult knockout mice, including an increase in oxidative stress and a decrease in the number of parvalbumin (PV) interneurons.47Therefore, redox imbalance may represent the main trigger for brain alterations before disease onset, which negatively influence cognition later on....
Hydroxyurea is a medication that is currently being used in adults and children with severe pain from sickle cell anemia. It is also considered for those with recurrent strokes and frequent transfusions. This drug acts by increasing the amount of fetal hemoglobin in the blood (this form of hemo...
Yes. While many moles arise in the first years of life, the total number of moles typically peaks in the second or third decade of life to an average of 35. Most people do not develop new regular moles after the age of 30. Adults often develop non-mole growths like freckles,lentigines...