IL-15 AND IL-15RαSUSHI DOMAIN BASED IMMUNOCYTOKINESTechnical problems to be solved are: providing that new immune and they are as drug, especially for treating cancer.モリソー セバスチャン ダニエルテッパ ジェラルディーヌジャック ヤニク ローラン ジョセフ...
Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha....
2.1.1RLI (IL-15-linker-IL-15 Rα sushi domain) 2.1.1.1Composition In 2006, RLI was generated by a French group who coupled human IL-15 with the high-affinity IL-15 binding domain (sushi domain) of human IL-15 Rα through a linker[17](Fig. 3). IL-15 Rα, like IL-2 Ra, co...
linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R± or derivatives thereof; and uses ...
The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. To investigate the importance of the IL-15Ralpha cytoplasmic domain, we generated a chimeric receptor consisting of the extracellular domain of IL-15Ralpha ....
本发明涉及基于IL‑15和IL‑15RαSUSHI结构域的免疫细胞因子。本发明的免疫细胞因子包括(a)缀合物,和(b)直接地或间接地共价连接至所述缀合物的抗体或所述抗体的片段,其中所述缀合物包括(i)包括白细胞介素15或其衍生物的氨基酸序列的多肽,和包括IL‑15Rα的sushi结构域或所述IL‑15Rα的sushi结构域的...
directly or indirectly by covalency to the conjugate; and its use, said The conjugate comprises (i) a polypeptide comprising the amino acid sequence of interleukin 15 or a derivative thereof and a polypeptide comprising the amino acid sequence of the sushi domain of IL-15R or a derivative ...
We have previously shown that a natural soluble form of IL-15R alpha chain corresponding to the entire extracellular domain of IL-15R alpha behaves as a high affinity IL-15 antagonist. In sharp contrast with this finding, we demonstrate in this report that a recombinant, soluble sushi domain ...
摘要: 本发明涉及一种免疫细胞因子,所述免疫细胞因子包含:(a)缀合物,和(b)通过共价键直接或间接连接至所述缀合物的免疫调节抗体或其片段,其中所述缀合物包含:(i)包含白细胞介素15或其衍生物的氨基酸序列的多肽,和包含IL-15Rα的sushi结构域或其衍生物的氨基酸序列的多肽;以及涉及所述免疫细胞因子的用途....
本研究旨在基于分子对接和表面等离子体共振(surface plasmon resonance,SPR)技术,挖掘与白细胞介素15受体α(interleukin-15 receptorα,IL-15Rα)特异性结合并影响其... 贺毅,王海霞,刘敏,... - 《生理学报》 被引量: 0发表: 2023年 IL-15RALPHA SUSHI DOMAIN AS A SELECTIVE AND POTENT ENHANCER OF IL-15 ...