Higgs团队联合在Cell杂志上发表了文章Super-enhancers include classical enhancers and facilitators to fully activate gene expression。作者提出了一个新概念:促进子。促进子没有内在的增强子活性,但在其缺失的情况下,经典增强子上调靶基因的功能会被减弱。本文为进一步研究超级增强子的调控机制提供了一个新的方向,值得...
2023年12月14日,英国约翰·拉德克利夫医院的Mira Kassouf和Douglas R. Higgs团队联合在Cell杂志上发表了文章Super-enhancers include classical enhancers and facilitators to fully activate gene expression。作者提出了一个新概念:促进子。促进子没有内在的增强子活性,但在其缺失的情况下,经典增强子上调靶基因的功能会被...
1. Enhancer 与 Super-enhancers 1.1. 增强子(Enhancer) 所谓增强子(Enhancer),位于结构基因附近,是一类非编码DNA顺式作用元件,在真核生物的发育过程中通过结合转录因子、辅因子以及染色质复合物作用于启动子,可以激活或增强基因的转录。简单说:增强子是能够增加启动子活性从而增加基因转录频率的DNA序列。 图1....
1.3. SEs鉴定 超级增强子(SEs, Super-enhancers )鉴定分析:可以找到影响转录水平异常增加的一系列表观水平的相互作用区域 SEs鉴定能给出什么信息? SEs的定义,分析意义,分析方法等简介目录浏览1 . ChIP-seq 1.1. ChIP-seq可以告诉我们什么信息 1.2. TF-chip与Histonechip 1.3. superenhancer的分析 1.4. 高级...
The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation, and regeneration, are critical to maintain stem cell identity which is sustained by genetic and epigenetic factors. Super-enhancers (SEs), which consist of cl
Although there are pipelines which use independent pieces of software to predict the presence of superenhancers from genome-wide chromatin marks or DNA-interaction protein binding sites, there is not yet an integrated software tool that processes automatically algebra combinations of raw data sequencing ...
These results suggest that super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers, and importantly, most of the stretch enhancers that are distinct from super-enhancers do not show an association with cell identity genes, are less active, and more likely to ...
Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor sampl
Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by altering protein-coding gene expression and noncoding regulatory element function. Therefore, they pla...
The term 'super-enhancer' has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin immunoprecipitation and sequencing (ChIP-seq). Here we review the identification and composition of super-enhancers, desc...