Higgs团队联合在Cell杂志上发表了文章Super-enhancers include classical enhancers and facilitators to fully activate gene expression。作者提出了一个新概念:促进子。促进子没有内在的增强子活性,但在其缺失的情况下,经典增强子上调靶基因的功能会被减弱。本文为进一步研究超级增强子的调控机制提供了一个新的方向,值得...
2023年12月14日,英国约翰·拉德克利夫医院的Mira Kassouf和Douglas R. Higgs团队联合在Cell杂志上发表了文章Super-enhancers include classical enhancers and facilitators to fully activate gene expression。作者提出了一个新概念:促进子。促进子没有内在的增强子活性,但在其缺失的情况下,经典增强子上调靶基因的功能会被...
Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identified as crucial p...
forming a longer, more intense enhancer clusters than typical enhancers (TEs) [6]. A super transcriptional regulation complex or platform is consists of Mediators, RNA polymerase II and super-enhancer bound with very high amounts of TFs [7] (Fig.1). The spatial, complexity and dynamic...
The various surrogate marks of typical enhancers include H3K27ac, H3K4me1, p300 and DNase, and the histone H3K27ac modification is superior to the others in mESC.4,6,28,29,30,31 A catalog of super-enhancers has been generated for 86 human cell and tissue types, and these SEs have ...
Super-enhancers include classical enhancers and facilitators to fully activate gene expression Cell (Dec 21 2023) WuC. et al. Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection American journal of transplantation : official ...
Recently, a novel class of enhancers has been described, the class of super enhancers (SE) [14], [15]. SEs are much larger than classical enhancers (typically 1–10 kbp in size) and are master regulators of cell identity genes, including developmental TFs and other components determining ...
Here we show that active super-enhancers are highly and specifically hypermutated in 92% of samples from individuals with DLBCL, display signatures of activation-induced cytidine deaminase activity, and are linked to genes that encode B cell developmental regulators and oncogenes. As evidence of ...
Super-enhancers (SEs) govern macrophage polarization and function. However, the mechanism underlying the signal-dependent latent SEs remodeling in macrophages remains largely undefined. Here we show that the epigenetic reader ZMYND8 forms liquid compartm
It might be that we overestimated as how ethically sensitive or important people view enhancers. If people generally saw enhanc- ers as something rather neutral, there would likely be only little variance in AoE and, in turn, low potential for cor- relations with other variables. However, we ...