Neurocysticercosis is the most common parasitic infestation of the central nervous system, which manifests commonly as acute-onset focal seizures. We report a rare nonepileptic manifestation of neurocysticercosis: midbrain neurocysticercosis presenting as sudden-onset ptosis in 2 children. To our ...
It has been reported that the first infection is either asymptomatic or results in nonspecific symptoms, such as an eruptive disease, febrile seizures (FS), or febrile status epilepticus [1], [2], [3], [5], [11], [12]. Subsequent HHV-7 infection is mainly limited to lymphocytes, ...
Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dys- function are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the ...
13 Truncating variants in TTN account for up to 25% of idiopathic DCM, but onset typically occurs in the fifth and sixth decades of life. Arrhythmogenic cardiomyopathy ACM is characterized by an enlarged, dilated right and/or left ventricle with or without decreased systolic function and ...
Sudden unexpected death in epilepsy patients (SUDEP) represents the second main neurologic cause of years of potential life lost, following stroke, with a cumulative lifetime risk reaching 8% for childhood-onset epilepsy. In light of these worrying figures, the American Academy of Neurology (AAN)...
seizures to death. Here, we summarize evidence for the mechanisms that cause cardiac, respiratory and arousal abnormalities during the ictal and postictal period. We highlight potential cellular mechanisms underlying these abnormalities, such as a defect in the serotonergic system, ictal adenosine ...
SUDEP incidence peaked in individuals aged 30–49 years. Body mass index, age at onset, and recent high-frequency generalized tonic-clonic seizures significantly increased SUDEP risk, with high-frequency seizures being the strongest predictor. Epilepsy duration, consciousness status during seizures, and...
Global heterozygous knockout (KO) of Scn1a is a popular model for DS and leads to an early onset of seizures, starting at P21 [109,110], with high susceptibility to hyperthermia [111]. The seizures are spontaneous with age-dependent severity [111]. The deaths are spontaneous, sporadic, ...
Global heterozygous knockout (KO) of Scn1a is a popular model for DS and leads to an early onset of seizures, starting at P21 [109,110], with high susceptibility to hyperthermia [111]. The seizures are spontaneous with age-dependent severity [111]. The deaths are spontaneous, sporadic, ...