SUDEP has a reported incidence of 1-2 per 1000 patient years and represents the most common epilepsy-related cause of death. The presence and frequency of generalised tonic clonic seizures (GTCS), male sex, early age of seizure onset, duration of epilepsy and polytherapy are all predictors of...
In the investigation of sudden death in adults, channelopathies, such as long QT syndrome, have risen to the fore in the minds of forensic pathologists in recent years. Examples of these disorders are touched upon in this review as an absence of abnormal findings at postmortem examination is ...
Molecular autopsy in sudden unexplained death (SUD) has successfully identified pathogenic variants in cardiovascular genes in a substantial proportion of cases, contributing to prevention strategies in family members. However, many SUD cases remain genetically unresolved, prompting investigations into other o...
Sudden cardiac death is defined as a natural death with sudden loss of consciousness within one hour of the onset of symptoms in a subject with or without known heart disease. The global incidence of sudden adult death is estimated at 20–100 cases per 100,000 person-years [1]. Sudden ...
Lack of clinical review of epilepsy in last 12 months Early onset of epilepsy (<16 years old) Active seizures: seizures in last 12 months Duration of epilepsy (>15 years) Convulsive seizures: generalised tonic clonic seizures in 12 months Young age (20−40 years old) Uncontrolled seizures ...
Sudden unexpected death in epilepsy patients (SUDEP) represents the second main neurologic cause of years of potential life lost, following stroke, with a cumulative lifetime risk reaching 8% for childhood-onset epilepsy. In light of these worrying figures, the American Academy of Neurology (AAN)...
This symptom consists of the inability to stay awake and alert during the day resulting in uncontrollable poor concentration and sudden sleep events. In addition to EDS, patients with narcolepsy may also suffer from the following: cataplexy, disrupted night-time sleep, sleep onset-related ...
onset of seizures. Computer tomography (CT) showed a left temporoparietal diffuse hypodense area, quite inhomogeneous without mass effect (Figure1, panel A). Cerebral MRI performed four years later confirmed the diagnosis of brain tumor. Over this time, the pattern of the seizures changed, ...
Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dys- function are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the ...
12 Genetic causes of DCM include causative variants in genes encoding the sarcomere, desmosome, cytoskeleton, and mitochondria.13 Truncating variants in TTN account for up to 25% of idiopathic DCM, but onset typically occurs in the fifth and sixth decades of life. Arrhythmogenic cardiomyopathy ACM ...