fundamental issue,drug discoveryA fundamental issue plaguing drug discovery is the high failure rate. Funding of the failed research is a contributor to the high cost of medicines and consequently, the rising cost of health care. How can the failure rate of drug discovery be minimized and the ...
The Tufts Center for the Study of Drug Development observed that pharma companies spend around $2.6 billion across 10-12 years to get a new drug to the market.1 This high price becomes even more significant in light of the fact that the success rate of clinical trials is just 10%-12%....
Biologic products advance through clinical development with a higher success rate than traditional small molecules, a new analysis of clinical development success from Informa Pharma Intelligence, the Biotechnology Industry Organization and the Quantitative Life Sciences shows.“Biological complexity in drug mo...
sequence type (ST) 11 is the dominant clone, responsible for infections correlated with a high in-hospital mortality rate of 33.5%2. Of concern is the emergence of hypervirulent carbapenem-resistantK. pneumoniae(hv-
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Complement positive reaction and target binding rate of tumor-related immune autoantibodies positive cells before and after treatment. *P < 0.05; **P < 0.01; ***P < 0.0001. Full size image Figure 2 Mean immunofluorescence intensity (MFI) of complement and tumor-associated immune auto...
14.Meanwhile, Turin is pressing ahead with his hypothesis."At Flexitral we have been designing odorants exclusively on the basis of their computed vibrations," he says."Our success rate at odorant discovery is two orders of magnitude better than the competition." At the very least, he is pu...
Compared to 2010, the mortality rate in 2015 dropped by 57 percent while the discovery rate increased by over 68 percent. Wu Zunyou, head of the AIDS and HIV prevention and control center of China Center for Disease Control and Prevention (China CDC), said China's practice of expanding the...
rate in that there will be many genes with strong and obvious genetic evidence for a trait that we miss, such as protein coding variants. Our aim however is not to perfectly catalog all genetically associated genes for these traits, but rather to test the validity of our network and ...
My concerns about Calne’s clinical judgment increased when he insisted on the use of Cyclosporine, despite the drug’s largely unknown side effects. Subsequently, experience revealed that the use of Cyclosporine alone correlated with nephrotoxicity and ...