Successful Drug Discovery 9783527826872 格式:PDF 页数:304 上传日期:2021-03-03 10:36:13 浏览次数:83 下载积分:10000 加入阅读清单 0% 0% 还剩299 页未读,是否继续阅读? 此文档由 lyn5657 分享于 2021-03-03 继续免费阅读全文 不看了,直接下载...
Mechanism of action is a central feature of drug discovery. Mechanism takes on different meanings depending on the stage of drug discovery, development, registration, and use. The molecular mechanism of action (MMOA) of a medicine connects specific molecular interactions to the response. This ...
In the first part, Gerd Schorrenberg, the Chair of the IUPAC Subcommittee of Drug Discovery and Development, gave an overview on new trends in drug research. He wrote in his chapter that the differences between New Chemical Entity (NCE) and the New Biological Entity (NBE) discoveries are beg...
Electronic discovery.Computer ForensicsThe field of computer forensics was developed primarily by law enforcement personnel for investigating drug and financial crimes. It employs strict protocols to gather information contained on a wide variety of electronic devices, using forensic procedures to locate ...
Nature Reviews Drug Discovery (2024) Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques Alexander Kistner Jessica A. Chichester Barbara A. Sullivan Gene Therapy (2024) Fidanacogene Elaparvovec: First Approval Sohita Dhillon ...
The proportion of NK cells was associated with the molecular relapse-free survival as patients with higher than median NK-cell percentage at the time of drug discontinuation had better probability to stay in remission. Similar association was not found with T or B cells or their subsets. In ...
Investments in the discovery and optimal use of new drug technology are practical reflections of the quality-ladder model of innovation. They drive improved duration and quality of life and accompanying economic productivity (Montague et al. 2002). The nature and ubiquity of care gaps causes one ...
Discovery of virulence factors of pathogenic bacteria Curr. Opin. Chem. Biol., 12 (2008), pp. 93-101, 10.1016/j.cbpa.2008.01.023 View PDFView articleView in ScopusGoogle Scholar Xu et al., 2021 Z. Xu, B. Green, N. Benoit, J.D. Sobel, M.C. Schatz, S. Wheelan, B.P. Cormack...
We also demonstrate that it is feasible to desensitize patients with APS and recommend an eculizumab dosing regimen that allows for the maintenance of therapeutic serum levels of the drug during plasmapheresis. The pathophysiology of thrombosis in APS and CAPS remains incompletely understood. Whether ...
This discovery allowed their relevance to the initiation or persistence of chronic pain to be proven and, quite importantly, to repurpose sulfasalazine, an old drug approved for inflammatory bowel disease therapy, for chronic pain treatment on a ration...