Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat. Struct. Mol. Biol. 2004; 11 :1101–1106. [ PubMed ]Weinger JS, Parnell KM, Dorner S, Green R, Strobel SA. Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol. 2004; 11...
A highly conserved threonine in the active site of cytochromes P450 has been proposed to participate in O2binding and cleavage. Cytochrome P450eryF is unusual in having alanine in place of this threonine and an ordered active site water molecule (Wat 519) which is hydrogen bonded to the substr...
The strategy is based on substrate-assisted antibody catalysis and utilizes analogs designed to mimic the transition-state for intramolecular catalysis and thereby favor antibodies that can recruit catalytic groups from substrate. The hydrolysis of the benzoyl ester of cocaine provides an illustration. ...
Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase 来自 Semantic Scholar 喜欢 0 阅读量: 32 作者:M Theuser,C H?Bartner,MC Wahl,KF Santos 摘要: The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA–protein complex (di-snRNP) during spliceosome ...
Substrate-Assisted Catalysis: Molecular Aspects Behind Unique Structural Switches Along Ohr Catalytic Cycle A new strategy in transition-state analog design is demonstrated to elicit catalytic antibodies. The strategy is based on substrate-assisted antibody catal... RM Domingos,RD Teixeira,A Zeida,......
N. 2001. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. J. Biol. Chem., 276(13): 10330-1033.Mark BL, Vocadlo DJ, Knapp S, Triggs-Raine BL, Withers SG, James MN. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-...
Quantum Mechanics/Molecular Mechanics Modeling of Substrate-Assisted Catalysis in Family 18 Chitinases: Conformational Changes and the Role of Asp142 in Catalysis in ChiB 来自 Semantic Scholar 喜欢 0 阅读量: 64 作者: Jitrayut Jitonnom, Vannajan S. Lee, Piyarat Nimmanpipug, Heather A. ...
Histidine 57 of the catalytic triad of was replaced with alanine to determine whether the resulting variant would be capable of substrate-assisted catalysis [Carter, P., & Wells, J. A. (1987) Science 237, 394-9]. A 2.5-fold increase in kcat/Km was observed on tri- or substrates contain...
(2012) Substrate- assisted catalytic mechanism of O-GlcNAc transferase discovered by quantum mechanics/molecular mechanics investigation. J. Am... Igor Tvaroska,S Kozmon,Michaela Wimmerova,... - 《Journal of the American Chemical Society》 被引量: 33发表: 2012年 Insights into the regulation of...
The binding (monodentate or bidentate) of the substrate to a zinc ion plays a significant role in the tautomerization. Both binding modes could complete the tautomerization and hydrolysis; however, the monodentate mode and five-coordination might be the most likely binding mode. For the bidentate ...