The BTB-containing protein MEL-26 functions as a substrate-specific adapter of a novel type of E3-ligase.Pintard, LionelWillis, JohnWILLEMS, AndrewJohnson, JacqueLynne FSrayko, MartinKurz, ThimoGlaser, SarahMains, Paul ETYERS, MikeBowerman, Bruce...
Our results support a model of S2P substrate specificity in which a substrate-specific adapter protein tethers the S2P to its substrate while holding the protease inactive through its PDZ domain. 展开 关键词: REGULATED INTRAMEMBRANE PROTEOLYSIS ANTI-SIGMA FACTOR MYCOBACTERIUM-TUBERCULOSIS ESCHERICHIA-COLI...
This was unexpected, since it had previously been anticipated that RNA-binding specificity would largely be determined by Air1 and Air2, which are Zn-knuckle RNA BPs26,40, or by specific interactions of AIM-containing proteins with the arch domain of Mtr415,16. When bound to the exosome, ...
A molded plastic adapter (10) for an electrical connector assembly (14) includes a rectangular first slot (26) for receiving a terminal support block (12) having electrical terminals (18) mounted therein. Guide portions (30) of the assem... ES Faber,JJ Hovan,WJ Sinsheimer - US 被引量:...
Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Pro...
Here, we use crosslinking to assemble pseudohexamers with WT or mutant pore-1 loops at specific positions and demonstrate unique functions for the D1 versus the D2 pore loops during the degradation process of both ssrA-tagged proteins and N-degron substrates delivered by the ClpS adapter (...
The array substrate, the display panel, and the display terminal provided by the embodiments of the present disclosure are described in detail above. The specific examples are applied in the description to explain the principle and implementation of the disclosure. The description of the above embodi...
E3 ubiquitin ligases directly recognize protein substrates for ubiquitylation and are thus the primary determinants of specificity within the UPS. This is thought to be achieved largely through their ability to selectively recognize specific molecular features of their substrates, which are known as degron...
Firstly, we reassessed the growth extent and specific growth rates using these substrates. Notably, we could not use the minimal medium designed for S. bryantii [18] in experiments since X. ruminicola KHP1 showed no growth in it. We opted instead for a modified DSMZ medium 330 used ...
Here, we show that p97, with its adapter p37, binds an internal recognition site (IRS) within inhibitor-3 (I3) and then threads a peptide loop into its channel to strip I3 off protein phosphatase-1 (PP1). Of note, the IRS is adjacent to the prime interaction site of I3 to PP1, ...