ADP on the one hand and the oxidation of [1- 14C]glutamate to 14CO 2 on the other, under a wide variety of conditions of respiration, suggesting that the substrate-level phosphorylation linked to the oxidation of 2-oxoglutarate leads to the phosphorylation of AMP in rat liver mitochondria. ...
recognize their cognate substrates in a phosphorylation-de- pendent manner (9, 16–19). CSN (COP9 signalosome) is an eight-subunit assembly and is highly homologous to the lid of the 26 S proteasome regula- tory particle (20–22). It is required for cell cycle progression ...
subunit and casein were well in accord with the inhibition pattern against the ATP-dependent proteolysis of the 26 S proteasome, suggesting that the phosphorylation of casein by a protein kinase associated with the 26 S proteasome is linked to the ATP-dependent proteolysis of the 26 S proteasome...
Phospho-Akt substrate-specific antibodies from Cell Signaling Technology are powerful tools for investigating the regulation of phosphorylation by Akt and other Arg-directed kinases, as well as for high throughput kinase drug discovery. Montminy, M. (1997) Annu Rev Biochem 66, 807-22. Pearson...
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth1. Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that catalyse the phosphorylation of tho
of known degrons comprise short linear motifs lying in accessible regions of proteins2. Degrons can either act constitutively, promoting continuous degradation of the protein, or conditionally, allowing protein turnover to be regulated through post-translational modifications such as phosphorylation3. ...
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and l... Author: Eduardo Pauls, et. al. Year: 2014 Page 1 of 6 限制使用 除非CST 的合法授书代表以书面形式书行明确同意,否书以下条款适用于 CST、其关书方或分书商提供的...
Owing to this mechanism, the phosphorylation of TFEB—unlike other substrates of mTORC1, such as S6K and 4E-BP1— is strictly dependent on the amino-acid-mediated activation of RagC and RagD GTPases, but is insensitive to RHEB activity induced by growth factors. This mechanism has a ...
Activation of hormone-sensitive lipase occurs by phosphorylation of this enzyme in several serine residues. Upon activation of Agrp neurons, we found decreased levels of phosphorylated hormone-sensitive lipase (p-HSL) in WAT compartments (Fig. 4e and Supplementary Figure 6). Together, these ...
G-protein-linked receptor kinaseinsulin receptor tyrosine kinaseThe ability of the cytoplasmic, full-length C-terminus of the 尾2-adrenergic receptor (BAC1) expressed in Escherichia coli to act as a functional domain and substrate for protein phosphorylation was tested. BAC1 was expressed at high-...