Inmetabolism: Substrate-level phosphorylation In substrate-level phosphorylation a phosphoryl group is transferred from an energy-rich donor (e.g., 1,3-diphosphoglycerate) to ADP to yield a molecule of ATP. This type of ATP synthesis (reactions [7], [10], and [43]) does not require molecu...
Substrate-level phosphorylation is one of the ways in which a phosphate group is introduced into a molecule. Another is oxidative phosphorylation. In substrate-level phosphorylation, the PO43-from a phosphorylated substrate is transferred to ADP to form ATP.Phosphorylases and kinasescatalyse this proce...
The decreased level of receptor phosphorylation was explained by a reduced number of receptors containing phosphorylated tyrosine residues (64.6 +/- 5% of control, P < 0.05). Glucocorticoid excess decreased skeletal muscle IRS-1 content by 50%, but did not significantly alter the total level of ...
Activation of hormone-sensitive lipase occurs by phosphorylation of this enzyme in several serine residues. Upon activation of Agrp neurons, we found decreased levels of phosphorylated hormone-sensitive lipase (p-HSL) in WAT compartments (Fig. 4e and Supplementary Figure 6). Together, these ...
The increased tyrosine phosphorylation level generated by Y508F and Y532F mutations is an unexpected outcome which cannot be simply explained by the tyrosine residues propensity to be phosphorylated by Src kinase. However, reminding that EYA proteins may autodephosphorylate6, the results in Fig. 2...
However, FK506 partially inhibits chemLTD, while it appears to have no effect on GluR1 phosphorylation. This difference could be explained if the dephosphorylation of AMPA receptors at the Schaffer collateral synapses was more sensitive to the drug than the dephosphorylation of the larger pool of ...
7D). This is in contrast to OM mitochondrial H2O2 emission with Suc, which decreased significantly during state 3 respiration but returned to state 2 level of H2O2 emission upon returning to state 4 after phosphorylation of the added ADP (Fig. 7F). In contrast, cortex mitochondrial H2O2 ...
This decrease in fructose 2,6-bisphosphate is brought about, at least in part, by a cAMP-dependent phosphorylation and inactivation of the enzyme responsible for its synthesis, 6-phosphofructo-2-kinase. This novel enzyme catalyzes the transfer of the γ phosphate of ATP to the C2 position of ...
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses that regulate their structure and function in health and disease. Here, we review EC responses to substrate-derived biophysical cues, namely topography, curvature
Lee et al. BMC Bioinformatics 2011, 12:261 http://www.biomedcentral.com/1471-2105/12/261 RESEARCH ARTICLE Open Access PlantPhos: using maximal dependence decomposition to identify plant phosphorylation sites with substrate site specificity Tzong-Yi Lee*, Neil Arvin Bretaña and Cheng-Tsung Lu ...