Substrate-level phosphorylationNeurodegenerationAKadenylate kinaseANTadenine nucleotide translocase@a-KGalpha-ketoglutarateMethylene blue (MB), a potential neuroprotective agent, is efficient in various neurodegenerative disease models. Beneficial effects of MB have been attributed to improvements in mitochondrial ...
Annotation of the human Tyr phosphoproteome by percentile scores with all RTK and nRTK motifs. 7,315 known human phosphorylation sites2,3were sorted along thexaxis according to the number of kinases that score the site in the 90th or higher percentile of substrates for that kinase. Independentl...
Activation of hormone-sensitive lipase occurs by phosphorylation of this enzyme in several serine residues. Upon activation of Agrp neurons, we found decreased levels of phosphorylated hormone-sensitive lipase (p-HSL) in WAT compartments (Fig. 4e and Supplementary Figure 6). Together, these ...
The increased tyrosine phosphorylation level generated by Y508F and Y532F mutations is an unexpected outcome which cannot be simply explained by the tyrosine residues propensity to be phosphorylated by Src kinase. However, reminding that EYA proteins may autodephosphorylate6, the results in Fig. 2...
However, FK506 partially inhibits chemLTD, while it appears to have no effect on GluR1 phosphorylation. This difference could be explained if the dephosphorylation of AMPA receptors at the Schaffer collateral synapses was more sensitive to the drug than the dephosphorylation of the larger pool of ...
Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases. Biochem J. 2000;347(Pt 1):45–53. 48. Tahara EB, Navarete FD, Kowaltowski AJ. Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free ...
This decrease in fructose 2,6-bisphosphate is brought about, at least in part, by a cAMP-dependent phosphorylation and inactivation of the enzyme responsible for its synthesis, 6-phosphofructo-2-kinase. This novel enzyme catalyzes the transfer of the γ phosphate of ATP to the C2 position of ...
Lee et al. BMC Bioinformatics 2011, 12:261 http://www.biomedcentral.com/1471-2105/12/261 RESEARCH ARTICLE Open Access PlantPhos: using maximal dependence decomposition to identify plant phosphorylation sites with substrate site specificity Tzong-Yi Lee*, Neil Arvin Bretaña and Cheng-Tsung Lu ...
PMVK-produced MVA-5PP's competitive binding to CKI impedes the phosphorylation of -catenin at Serine 45, ultimately preventing its degradation. In a different manner, PMVK is a protein kinase that phosphorylates -catenin at serine 184 to enhance its nuclear accumulation. PMVK and MVA-5PP's ...
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses that regulate their structure and function in health and disease. Here, we review EC responses to substrate-derived biophysical cues, namely topography, curvature