IntroductionSubstance P (SP) which is produced by neuronal and non- neuronal cells has various functions. In addition to its role in pain transmission, this neuropeptide has effects on tissue matrix remodelling, cell growth, angiogenesis and inflammation.1,2 SP has previously been shown to be ...
Substance P modulates ion channels and the excitability of sensory neurons in pain pathways. Within the heterogeneous population of Dorsal Root Ganglia (DRG) primary sensory neurons, the properties of cells that are sensitive to Substance P are poorly characterized. To define this population better, ...
In addition, substance P is present in the excitatory neurones of the corpus striatum-substantia nigra pathway, which also has GABA-containing inhibitory neurones, and this pathway is known to modulate the dopaminergic nigra-striatum pathway. The global function of substance P, therefore, seems to...
The pain pathway thus detected had the following characteristics: For example, when the lateral side of the 5th finger of the left hand was pinched, the pathway was approximately along the ulnar nerve and then went to the dorsal root of the spinal cord around the area corresponding to the ...
Surprisingly, the mechanisms by which corticosteroids induce pain relief in this condition have not been investigated. Previous studies have shown local substance P (SP) levels to be correlated with tendon pain and tissue pathology. The objective of this study was to determine whether SP production ...
(Fig.8A). The lesional density of CGRP positive nerve fibers correlated with the pain severity in women with endometriosis (Spearman’s r = 0.85, p < 2.2 × 10−16). Concomitantly, lesional staining levels of α-SMA, NK1R, RAMP-1 (either epithelial or stromal), and CR...
We considered heroin use to be a more intensive level of opioid use than prescription opioid use disorder a priori because current evidence suggests that prescription opioid use is on the pathway to heroin use for most individuals who use heroin.17,18 Sociodemographic Variables We examined ...
When the brain senses injury to the body, pain signals begin in the somatosensory cortex and the hypothalamus and work their way through the "pain pathway," ultimately sending signals that provide pain relief. Some signals stimulate the release of neurotransmitters such as endorphins, dynorphins, ...
(Ji et al., 2018). The emerginglymphatic vesselsin the cornea provide a pathway by which mature dendritic cells travel to draininglymph nodes(Ji et al., 2018). Activated dendritic cells recruit T-cells into the cornea and the conjunctiva. When substance P concentration increases or its ...
p pWhile altered activities in sensory neurons were noticed in neuropathic pain, caused by highly diverse insults to the peripheral nervous system, such as... X Chen,JD Levine - 《Molecular Pain》 被引量: 71发表: 2007年 Electrophysiologic changes during exercise testing in patients with chronic...