Both groups find that when the function of SP is genetically disrupted in mice, the animals show reduced responses to painful stimuli.Leslie IversenNatureIverson L: Substance P equals pain substance?. Nature 1998; 392:334-335.Iversen L (1998) Substance P equals pain substance? Nature 392: 334...
Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain. Special emphasis is put on how to use this knowledge in the development of new ways...
Substance P, discovered originally in 1931 by von Euler and Gaddum, has taken over 40 years to be appreciated as an important naturally-occurring peptide in synaptic transmission in the mammalian central nervous system. Of its various possible roles, perhaps the most clearly substantiated by experime...
Parris WC,Sastry Bv,Kambam JR,et al.Immunoreactive substance P in human saliva.A possible marker of chronic pain. Annals of the New York Academy of ... MC Thurber,FA Wolak - 《Pain》 被引量: 0发表: 1981年 Keratinocyte expression of inflammatory mediators plays a crucial role in substance...
Objective There is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to...
C. : Increase of substance P in primary afferent nerves during chronic pain . Neuropeptides 1 : 175 – 180 , 1981 .Lembeck F, Donnerer J, Colpaert FC (1981) Increase of substance P in primary afferent nerves during chronic pain. Neuropeptides 1:175...
The global function of substance P, therefore, seems to keep the central nervous system in a state of alert through activation of the cerebral cortex and assistance in the transmission of pain. 展开 DOI: 10.1007/springerreference_39777 年份: 1981 ...
Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation : V.S. Seybold, J.L.K. Hylden and G.L. Wilcox (Departments of Anatomy and Pharmacology, Univ. of Minnesota Medical School, Minneapolis, Minn. 55455, U.S... Seybold VS, Hylden JL, Wilcox GL. Intrathecal...
Substance P in peripheral ... F Lembeck,R Gamse - 《Ciba Foundation Symposium》 被引量: 312发表: 1982年 If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function? In: Substance P in the Nervous System , pp. 249 – 261 . ...
After CFA-induced synovitis, pain behaviors were observed. Then, TMJ, trigeminal ganglion, and trigeminal nucleus caudalis (TNC) tissues were collected, and immunohistochemistry was used to detect the expression of substance P (SP) and protein gene product 9.5 (PGP9.5) in the synovium tissue. ...