1. A proposed mechanism of contractile action of substance P in guinea-pig ileum longitudinal smooth muscle involving a decrease in membrane K+ permeability (PK) has been re-examined. 2. Potentiation of responses to substance P by the K+ channel blocker tetraethylammonium (TEA) was originally ...
Molecular modeling suggests that this mechanism should involve EfTu unfolding and insertion into the bacterial cytoplasmic membrane, presumably through formation of homopolymers. This study is unraveling the original mechanism action of EfTu as a bacterial sensor but also reveals that this protein should...
The molecular mechanism of action of substance P (SP) analogue broad spectrum neuropeptide antagonists - Lung Cancerdoi:10.1016/S0169-5002(00)80647-9Seckl, M.JWeinglass, ALi, QElsevier Ireland LtdLung Cancer
Oxaliplatin, by contrast, did not increase the release of substance P. These results suggest that substance P is involved in paclitaxel-induced neuropathy, and the mechanism of its action is clearly different from that of oxaliplatin. 展开
[1].Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. [2].Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J...
Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. 1. Intracellular microelectrode recordings were used to study the cellular location, the receptor pharmacology, and the mechanism of action of adenosine on... SM Thompson,HL Haas,Ghwiler B ...
Capsaicin was administered as an aerosol to unanesthetized guinea pigs in a whole body plethysmograph and intravenously to anesthetized guinea pigs to investigate its mechanism of action. Capsaicin increased specific airway resistance in the unanesthetized guinea pigs and increased insufflation pressure in...
aInvestigation the mechanism of action for Liuwei Dihuang Tang and its drug substance basis on type 2 diabetes mellitus base on PI3K-Akt signaling pathway 调查行动为Liuwei Dihuang特性和它的药物物质依据机制在第二类型糖尿病mellitus基地在PI3K-Akt信号路[translate]...
Modulation of endopeptidase activity by CGRP: a mechanism affecting substance P action Substance PMicrodialysisCalcitonin gene-related peptideComplex regional pain syndromeNeurogenic inflammationTibia fracture in rats evokes nociceptive, vascular, and ... F Nyberg,PL Grevés,L Terenius 被引量: 52发表: 19...
18, 31 A possible mechanism of action of SP is by reducing oxidative stress. In the presence of increased oxidative stress, macrophages tend to adopt a more proinflammatory phenotype.32 In addition, SP reduces oxidative stress in corneal wound healing.33 In our mouse model, the skin ...