Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. Cardiovasc Diabetol. 2023;22(1):107. [13] Sunilkumar S, et al. REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice...
The treatment with the beta cell toxin streptozotocin is the standard procedure for triggering a chemically induced diabetes. Surprisingly, little data has been published about the reproducibility, stress and animal suffering in these NSG mice during diabetes induction. The 3R rules, however, are a ...
roots, which are widely used in inflammation, fever, ulcers, leucoderma and diabetes in various parts of India. SS was administered orally at different doses (250, 500 and 1000mg/kg) to normal and streptozotocin (STZ) induced type-2 diabetic mice. The fasting blood glucose (FBG), ...
Effect of MARK4 knockdown on body weight, blood glucose levels and oxidative stress in mice with STZ-induced DCM Weight change is a prominent feature of diabetes. As shown in Fig. 2A, the STZ injection started at 8 weeks, and the weight of the control group continued to increase, while ...
Objective This study aimed to investigate the susceptibility of mice with streptozotocin(STZ)-induced diabetes mellitus (TIDM) to the uptake of pentavalent inorganic arsenic (iAsⅤ) and the possible molecular mechanism. Methods TIDM was induced in mice by STZ. TIDM and normal mice were treated ...
Abstract:【Objective】To investigate the effect of imperatorin on liver damage, peroxidative stress and immune response in young rats with type I diabetes induced by streptozotocin (STZ).【Methods】Totally 50 BALB/c juvenile mice ...
5.Single-cell RNA sequencing analysis reveals the relationship of bone marrow and osteopenia in STZ-induced type 1 diabetic mice 6.Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. 7.Protective effects of sulforaphane on type 2 diabetes-induced cardiomyop...
[3]. Kim B, et al. Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism. Int J Mol Sci. 2023 Mar 8;24(6):5210. [4]. Gurley SB, et al. Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol. 2006 Jan;290(1...
Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90. [3]. Kim B, et al. Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism. Int J Mol Sci. 2023 Mar 8;24(6):5210. [4]. Gurley SB, ...
Here we used streptozotocin (STZ)-induced diabetic mice to study the effects of long-term hyperglycemia on CD4+CD25+ Tregs in vivo. Four months after the onset of diabetes, the frequency of CD4+CD25+Foxp3+ T regulatory cells was significantly elevated in the spleen, peripheral blood ...