Verlinde CL, Bressi JC, Choe J, et al. Protein structure-based design of anti-protozoal drugs. J Braz Chem Soc 2002; 13: 843-4.Verlinde, C.L.M.J., Bressi, J.C., Choe, J., Suresh, S., Buckner, F.S., Van Voorhis, W.C., Michels, P.A.M., Gelb, M.H., Hol, W.G....
The PUXANO technology platforms aim to accelerate structure-based protein research, from sequence to structure
Recent developments in protein design rely on large neural networks with up to 100s of millions of parameters, yet it is unclear which residue dependencies are critical for determining protein function. Here, we show that amino acid preferences at individual residues—without accounting for mutation ...
Structure-based design of molecular cancer therapeutics Structure-based design approaches have also been successfully applied to the protein–protein interaction targets p53–MDM2 and the Bcl-2 family... RLMV Montfort,P Workman - 《Trends in Biotechnology》 被引量: 198发表: 2009年 An Overview on ...
Structure-based Design and Biosynthesis of Collagen Proteins胶原蛋白结构基础上的设计与合成胶原蛋白生物合成基因工程羟化酶分子设计Collagen is the most abundant protein in human body and a periodic helix, i.e., triple helix, fibrous protein, which provides the scaffold structures for the cell adhesion...
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. Graphical abstract Using structure-based design, a new class of inhibitors of protein tyrosine phosphat...
design (CADD), which nowadays constitutes an essential part of the discovery pipeline at pharmaceutical companies [5•, 6•]. The CADD tools are commonly classified into ligand-based (two-dimensional, 2D) and protein structure-based (3D). In this review we will focus on the 3D methods ...
The human metapneumovirus (hMPV) fusion (F) protein is essential for viral entry and is a key target of neutralizing antibodies and vaccine development. The prefusion conformation is thought to be the optimal vaccine antigen, but previously described pre
Toledo LM, Lydon NB, Elbaum D (1999) The structure-based design of ATP-site directed protein kinase inhibitors. Curr Med Chem 6(9):775-805... LM Toledo,NB Lydon,D Elbaum - 《Current Medicinal Chemistry》 被引量: 151发表: 1999年 Structure-Based Design of Novel Chk1 Inhibitors: Insi...
Protein–ligand docking techniques are one of the essential tools for structure-based drug design. Two major components of a successful docking progra... S Woong‐Hee,H Lim,L Juyong,... - 《Journal of Computational Chemistry》 被引量: 44发表: 2011年 ChemInform Abstract: Synthesis of N‐Isobu...