The amino acid sequence of Byr2's Ras binding domain is only weakly related to that of Raf, and Byr2's three-dimensional structure is unknown. Results: We have solved the 3D structure of the Ras binding domain of Byr2 (Byr2RBD) from Schizosaccharomyces pombe in solution. The structure ...
Structure and biological activity of human homologs of the raf/mil oncogene. Mol Cell Biol 1985;5:1400-7.Bonner TI, Kerby SB, Sutrave P, Gunnell MA, Mark G, Rapp UR. 1985. Structure and biological activity of human homologs of the raf/mil oncogene. Mol Cell Biol 5:1400-1407....
TPS145 Background: The Ras/Raf/MEK/ERK cascade is frequently activated in human cancers; MEK inhibition is an attractive therapeutic target for preventing ... AA Adjei,P Lorusso,A Ribas,... 被引量: 0发表: 2017年 Valmiki's Palm one of my mother's sloping flowerbeds, turned the faucet...
Theplasmid-borne raf operonencodes functions required forinducible uptake andutilization ofraffinose by Escherichia coli. Raffunctions include active transport (Rafpermease), a-galactosidase, andsucrose hydrolase, which arenegatively controlled bytheRafrepressor.We havedefined theorder andextent ofthe three ...
Mutations of the p53-related protein kinase (PRPK) and TP53RK-binding protein (TPRKB) cause Galloway-Mowat syndrome (GAMOS) and are found in various human cancers. We have previously shown that small compounds targeting PRPK showed anti-cancer activity a
During the past few years a number of investigations have demonstrated that genetics plays a significant role in the ability of several animal species to elicit immune responses to a variety of antigens (McDevitt and Benacerraf, 1969). R... E Mozes,GM Shearer,M Sela,... - Springer Berlin...
The SHOC2–MRAS–PP1C holophosphatase complex functions as a key regulator of RTK–RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins to potentiate MAPK signalling1. SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function...
1998a). Water molecules that are not bound to other compounds are bound to each other, forming tetrahedron structures (so-called tetrahedron or bulk water) (Walrafen 1972;Nielsen 1979,1993,1997;Maeda & Kitano 1995;Nielsenet al. 1997). An understanding of the changes in water structure in ...
(B) Superposition of the RAF structural module. The relative conformations of these two structural modules could be adjusted by rotation about the Gly-Arg junction as a pivot point. Table 3. Main Chain Dihedral Angles (°) of the V3 Loop Insert in the MN-III-2 Chimeric Virus and Comparison...
Mapping Precambrian structures in the Sahara Desert with SIR‐C/X‐SAR radar: The Neoproterozoic Keraf Suture, NE Sudan A major N-trending Neoproterozoic suture between composite arc terranes of the Arabian-Nubian Shield in the east and older crust of the Nile Craton to the ... MG Abdelsalam...