Subunit fine structureGenetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crys...
The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby ensuring accuracy in translation of the genetic message in a process called d
The 30S ribosomal subunit binds messenger RNA and the anticodon stem-loop of transfer RNA during protein synthesis. A crystallographic analysis of the structure of the subunit from the bacterium Thermus thermophilus is presented. At a resolution of 5.5 Å, the phosphate backbone of the ribosoma...
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However, the functions of many of the individual protomers within the ribosome are still unknown. In this article, we describe the solution NMR structure of the ribosomal protein RP-L35Ae from the archaeon Pyrococcus furiosus. RP-L35Ae is buried within the large subunit of the ribosome and ...
Structure of the Yeast Mitochondrial Large Ribosomal Subunit Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mit... A Amunts,A Brown,Xiao-chen Bai,... - 《Science》 被引量: 410发表: 2014年 ...
The structure of the ribosome with elongation factor G trapped in the post-translocational state (Part 1 of 4). The ribosome is in an unusual state of ratcheting with the 30S subunit rotated clockwise relative to the 50S subunit, resulting in a remodeled decoding ... Y Gao,M Selmer,C Du...
vip药学学报(英文版)Mwangi HNU, Wagacha P, Mathenge P, Sijenyi F, Mulaa F (2017) Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling. Acta pharmaceutica sinica B 7(1): 97-105.
Structure of the 30S ribosomal subunit. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 A resolution. The final atomic model rationalizes over ... BT Wimberly,DE Brodersen,CW Jr,... - 《Nature》 被引量: 4151发表: 2000年 Crystal structure of...
et al. A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure 15, 289–297 (2007). 24. Schmeing, T. M. et al. A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat. Struct. Biol...