EXPLAIN:Electrospray ionization mass spectrometry of a protein. (a) A protein solution is dispersed into highly chargeddropletsby passage through a needle under the influence of a high-voltage electric field. The droplets evaporate, and the ions (with added protons in this case) enter the mass s...
Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by specifically degrading the protein cofactors VIIIa and Va (Figure 1). The biological role of...
Protein Synthesis and Ribosome Structure 2024 pdf epub mobi 电子书 图书描述 Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, fin...
The former now provides a complete package for the solution of protein crystal structures and uses the well known refinement techniques from x-plor. Recent addition of atomic anisotropic temperature factor refinement to refmac [40•] and its integration into the ccp4 suite make this the ...
The peptidyl carrier protein (PCP) domain is the canonical, key player in the modular assembly line methodology ofNRPSs(Fig. 3).12The domain is responsible for carrying and delivering the intermediates in thepeptide synthesischemistry to the variousenzymesof theNRPS. ThePCP domainis post-translation...
A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ra...
protein sequence of AmAT7-3 did not cluster with other acyltransferases and formed a relatively distinct branch, indicating its high sequence specificity (Fig.1a, b). The distribution of AmAT7-3, AmAT8-17, and the six known glycoside ATs explained the challenges in predicting the function of ...
Proteins are highly complex substances present in all living organisms that are of great nutritional value and that are directly involved in the chemical processes essential for life.
The iodobenzoic acid 4 was afterwards converted into the diaryl ether 2 by means of a copper-catalyzed Ullmann-like ether synthesis [21]. Thereby, it was coupled with 4-fluorophenol to obtain the 2-phenoxy scaffold 2. The nucleophilic aromatic substitution of 1-fluoro-2-nitrobenzene with N-...
Keratin, fibrous structural protein of hair, nails, horn, hoofs, wool, feathers, and of the epithelial cells in the outermost layers of the skin. Keratin serves important structural and protective functions, particularly in the epithelium. Learn more abo