Structure of MHC class I and class II cDNAs and possible immunodeficiency linked to class II expression in the Mexican axolotl. Immu- nol. Rev. 166, 259e277.Tournefier A, Laurens V, Chapusot C, Ducoroy P, Padros MR, Salvadori F, Sammut B: Structure of MHC class I and class II ...
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel β-...
The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for NKG2D, a C-type lectin-like activating immunoreceptor. The crystal structure of this ligand-receptor complex that we report here reveals an NKG2D homodimer bound to a MICA monomer in an interaction...
- 《European Journal of Immunology》 被引量: 113发表: 1993年 Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. Suppression of MHC class I expression is thought to allow tumor cells to ...
1b–e). As β2m-associated MHC class I molecules may restrict the recognition of C14nef5 by 2N5.1, we isolated an array of rhesus MHC (Mamu) class I complementary DNA clones from a donor with the potential to present C14nef5 to 2N5.1 and transfected each cDNA clone into the monkey ...
Complex structure of the activating immunoreceptor NKG2D and its MHC class I- like ligand MICA. Nat. Immunol. 2: 443-451.Li P,Morris DL,Willcox BE,et al.Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nature Immunology . 2001...
Activities of ATP binding cassette (ABC) proteins are regulated by multiple mechanisms, including protein interactions, phosphorylation, proteolytic processing, and/or oligomerization of the ABC protein itself. Here we present the structure of yeast cadm
During the past year, a plethora of structural information has provided detailed insights into the interactions between classical MHC class I molecules and their cognate receptors on T cells. Likewise, there have been major advances in our knowledge of the structures and functions of five nonclassical...
The BoLA appears to be organized in a similar way to the MHC region in humans, but there are notable differences. A major rearrangement within the class II region has led to the division of the BoLA into two distinct subregions of chromosome 23 separated by about a third of the chromosome...
The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differenc...