A recently developed membrane mimetic system called styrene maleic acid lipid particles (SMALPs) or lipodisq nanoparticles has shown to possess significant potential for biophysical studies of membrane proteins. This new nanoparticle system is composed of lipids encircled by SMA copolymers. Previous ...
A detailed description of the internal structure of the liquid and solid aggregates of tripalmitin and a solid lipid nanoparticle made of C18:1E10 surfactants and tripalmitin is provided.doi:10.1002/smll.201903156Demi L. PinkOrathai Loruthai...
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature condi...
it will set off subsequent hybridization of the crRNA to the target DNA strand and the formation of an R-loop structure. The PAM sequences of Cpf1 family proteins are predominantly T-rich and differ only in the number of thymidines. Also, it ...
cell–nanoparticle interactionsdrug delivery systemsliquid crystalline lipidsself‐assembled nanostructurestissue cytotoxicitySelf‐assembly of lipid‐based liquid crystalline (LLC) nanoparticles is a formulation art arising from the hydrophilic–lipophilic qualities and the geometric packing of amphiphilic lipid ...
5The tight gap allows only passive diffusion of lipid-soluble drugs at a molecular weight lower than 400-600 Da. Increasing lipophilicity of the therapeutic agents is a feasible method to improve the BBB permeability. For example, Crizotinib, an oral selective small-molecular tyrosine kinase ...
Changes in the structure can cause defects in these functions, which in some cases can result in the death of the cell and the organism. Thus, when investigating the effects of nanometre-sized materials on biological matter, the protein-nanoparticle interactions must be handled with priority. In...
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Although lipid nanoparticl... KJ Kauffman,JR ...
siRNA delivery to the liver is achieved with lipid nanoparticle formulations and conjugation of ligands such as N-acetylgalactosamine (GalNAc), which has a high affinity for asialoglycoprotein receptors (ASGPRs) that are predominantly expressed on hepatic parenchymal cells. Also, intrathecal delivery ...
Each construct was formulated as a lipid nanoparticle comprising the ATX-081 ionizable lipid. FIG. 11 shows the results of enhanced hGDF15 expression of mRNA constructs of this invention over the control mRNA construct 5′TEV-CDS-3′XbG in vivo at 24 hours post IV-administration in male 6-...