Gene, unit of hereditary information that occupies a fixed position on a chromosome. Genes achieve their effects by directing the synthesis of proteins. They are composed of deoxyribonucleic acid (DNA), except in some viruses, which have genes consisting
DNA wraps around the histone octamer to form nucleosomes1, the repeating unit of chromatin, which create barriers for accessing genetic information. Snf2-like chromatin remodellers couple the energy of ATP binding and hydrolysis to reposition and recompo
Advances in the genome-wide analysis of human genomic variation in disease states have led to the discovery of thousands of disease-associated loci1. Although genome-wide association studies (GWASs) have been successful in uncovering the contribution of single nucleotide polymorphisms (SNPs) to common...
The structure of a human common cold virus (rhinovirus 14) and its structural and functional relations to other picornaviruses and plant viruses. The structure of a human common cold virus (rhinovirus 14) and its functional relations to other Picornaviruses. In Crystallography in Molecular Biology,...
aSequences of the entire human genome reveal a relative richness in structure with repetitive elements, tandem repeats, inverted repeats, and palindrome structures. Focusing on structure, the evolution of X and Y chromosomes in primates is reviewed here, and the relationship between gene expression ...
of cytogenetic techniques, emphasizing their application to human genome studies and examinations. The book is divided into nine chapters. It explains the molecular organization and function of the human genome and the DNA sequences in man. It also discusses the localization of human gene by in ...
Here we present 3.3- to 3.5-Å-resolution cryoelectron microscopic structures of the mammalian 28S mitoribosomal subunit in complex with human IF3mt. Unique contacts observed between the 28S subunit and N-terminal domain of IF3mt explain its unusually high affinity for the 28S subunit, whereas...
Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active transporter present on the plasma membrane of most mammalian cells and plays critical roles in regulating intracellular pH and volume homeostasis. Calcineurin B-homologous protein 1 (
cleft and recruit FEN1 to one unoccupied monomer in a toolbelt fashion. Alternative holoenzyme conformations reveal important functional interactions that maintain PCNA orientation during synthesis. This work sheds light on the structural basis of Pol δ’s activity in replicating the human genome. ...
The Human Microbiome Project(HMP),also known as the second human genome project,was initiated by the National Institutes of Health(NIH) in 2007.HMP was a 5... NN Cheng,CL Guo - 《Indian Journal of Microbiology》 被引量: 2045发表: 2012年 The NIH Human Microbiome Project The Human Microbio...