According to nature's functional aesthetics principles, hepatitis C virus (HCV) came to acquire a certain structure to serve a specific purpose. Structure explains mechanisms, reveals strategies. In viruses, optimization of the shape is dictated by the number of encoded structural proteins and ...
Daniel Boehringer1, Marc Leibundgut1, Joop van den Heuvel2 & Nenad Ban1 Hepatitis C virus (HCV), a widespread human pathogen, is dependent on a highly structured 50-untranslated region of its mRNA, referred to as internal ribosome entry site (IRES), for the translation of all of its pro...
The hepatitis C virus (HCV) p7 viroporin is a membrane protein required for virus propagation in vivo that assembles into hexamers and heptamers in membranes, exhibits ion channel activity, and is an attractive target against HCV infection1. OuYang and colleagues reported an oligomeric structure ...
Translation of hepatitis C viral proteins requires an internal ribosome entry site (IRES) located in the 5′ untranslated region of the viral mRNA. The core domain of the hepatitis C virus (HCV) IRES contains a four-way helical junction that is integrated within a predicted pseudoknot. This do...
Interestingly, it has been shown that IRES (Internal Ribosome Entry Site)-mediated translation initiation of class III- and IV–IRES (e.g., in Hepatitis C Virus (HCV) and Cricket paralysis virus (CrPV)) respec tively, is immune to the NSP1 inhibition. Instead, the translation ...
Abstract: The hepatitis C virus 5′ untranslated region (HCV 5'UTR) contains secondary structures typical of internal ribosome entry site elements leading to translation. Variations of this secondary structure in relation to the efficacy of interferon (IFN) therapy were investigated. Methods: Natural ...
respectively [5,6,7]. Compared with SARS‐CoV and MERS‐CoV, SARS‐CoV‐2 is spreading more rapidly and causes much higher number of deaths. This emerging virus has promoted massive hospitalizations, lockouts, financial loss, unemployment, the closure of schools in nearly all countries [8]. ...
Bovine viral diarrhoea virus (BVDV) is a member of the genus Pestivirus, family Flaviviridae, that includes the causative agents of economically significant diseases of cattle, pigs, and sheep. The...
virus taxa, so we are unable to predict functions associated with these genes. In this work, we tried to determine if some of these genes were actually involved in IVs morphogenesis, using RNA interference technique. Our results show the feasibility of this experimental approach and confirm ...
Getah virus (GETV), a member of the genus alphavirus, is a mosquito-borne pathogen that can cause pyrexia and reproductive losses in animals. Although antibodies to GETV have been found in over 10% of healthy people, there are no reports of clinical symp