1. Draw a labelled diagram of the structure of DNA, showing the arrangement of subunits. [3 marks] 2. The diagram below represents a DNA nucleotide. Identify the phosphate group and deoxyribose. [1 mark] 3. Draw a labelled diagram to show how four nucleotides are joined together to form ...
it is the transparent, anterior or front part of our eye, which covers the pupil and the iris. the main function is to refract the light along with the lens. iris: it is the pigmented, coloured portion of the eye, visible externally. the main function of the iris is to control the ...
Due to its key role in various biological processes, RNA secondary structures have always been the focus of in-depth analyses, with great efforts from mathematicians and biologists, to find a suitable abstract representation for modelling its functional and structural properties. One contribution is du...
2.2. DNA Extraction and PCR Amplification The SteadyPure Universal Genomic DNA Extraction Kit (AGBIO, Changsha, China) was used to extract the whole genome in accordance with the manufacturer’s instructions. Twenty-one highly polymorphic fluorescently labelled microsatellite markers were amplified, includ...
Training with labelled and unlabelled data The AlphaFold architecture is able to train to high accuracy using only supervised learning on PDB data, but we are able to enhance accuracy (Fig.4a) using an approach similar to noisy student self-distillation35. In this procedure, we use a trained ...
with a strong preference for reticulocytes. Using X-ray crystallography, we solved the structure of the PVP01_0000100 C-terminal tryptophan rich domain, which defines the TRAg family, revealing a three-helical bundle that is conserved acrossPlasmodiumand has structural homology with lipid-binding ...
In addition, epochs labelled by N4 were relabelled to N3 according to the AASM standard. For more details on the database, we refer the reader to https://www.physionet.org/physiobank/database/sleep-edfx/. In our analysis we follow the state-of-the-art papers (Liu et al., 2018; ...
We have begun to understand the DNA sequences that are associated with chromosomal landmarks, such as centromeres, telomeres, chromosome bands, and fragile site; however, we still do not understand the role of such sequences in producing the associated functional correlates. For example, which ...
The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix1,2,3. Dysfunction of dystrophin and its associated proteins results in muscular dystrophy, a disorder chara...
Telomeric abnormalities caused by loss of function of the RecQ helicase WRN are linked to the multiple premature ageing phenotypes that characterize Werner syndrome. Here we examine WRN’s role in telomeric maintenance, by comparing its action on a variety of DNA structures without or with telomeric...