Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal DNA and generates RNA for ribosome synthesis. Pol I accounts for the majority of cellular transcription activity and dysregulation of Pol I transcription leads to cancers and ribosomopathies. Desp
-type regular structure when hybridizing with nucleic acids, they still take advantage of the presence of a nucleobase that can assure base pairing, and of the flexibility of the peptide backbone, which enables the conformational changes during the interaction with complementary single-strand DNA/RNA...
The primary structure of an RNA molecule may be understood as a sequence of amino acids: arginine, urasil, guanine, and cytosine. As is standard, we frequently abbreviate these as A, U, G, and C, respectively. RNA molecules are single-stranded and may therefore interact with themselves, ...
S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions. Biochemical studies have demonstrated that S100A4 binds to
The transmembrane DNA-binding protein CadC of E. coli, a representative of the ToxR-like receptor family, combines input and effector domains for signal sensing and transcriptional activation, respectively, in a single protein, thus representing one of the simplest signalling systems. At acidic pH ...
Molecular functions of A-to-I editing ADARs deaminate adenosine in dsRNA or the A-form helix (DNA: RNA hybrid) [46,47,48]. The introduction of non-canonical base pairs into the dsRNA structure increases complexity, which actually affects the efficiency of adenosine editing (Fig.2). The two...
gene 32 mRNA showing that the single-stranded loops L1 (green) and L2 (yellow) will cross the major and minor grooves of stems S2 (blue) and S1 (red), respectively, on the same face of the molecule provided the junction region conforms to near-normal A-form geometry (PDB code 2TPK)...
Why a Scientific Format?The scientific format may seem confusing for the beginning science writer due to its rigid structure which is so different from writing in the humanities. One reason for using this format is that it is a means of efficiently communicating scientific findings to the broad ...
Figure 1. Domain Diagram of Munc13-1 and Summary of Fragments Used in This Study (A) Domain diagram of rat Munc13-1. Residue numbers indicate selected domain boundaries. The predicted subdomains within the MUN domain are labeled A-D. CaMb indicates a calmodulin-binding sequence. The approximat...
a DNMT3L molecule via the FF interface. Nevertheless, detailed structural comparison of the two complexes revealed subtle yet functionally important differences in substrate recognition, with the RD interface of DNMT3A engaging stronger DNA contacts than that of DNMT3B22,23,26. Furthermore, the DNA...