select article Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS Research articleOpen access Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS Kenta Kudo, Karin Hori, Se...
L. Fast photochemical oxidation of proteins and mass spectrometry follow submillisecond protein folding at the amino-acid level. J. Am. Chem. Soc. 134, 18724–18731 (2012). CAS PubMed PubMed Central Google Scholar Li, K. S., Rempel, D. L. & Gross, M. L. Conformational-sensitive ...
Iron is a limiting nutrient in bacterial infection putting it at the centre of an evolutionary arms race between host and pathogen. Gram-negative bacteria utilize TonB-dependent outer membrane receptors to obtain iron during infection. These receptors ac
For example, an individual cell of a leaf cannot perform all of the functions of the leaf, but the cells of the leaf collectively perform the function of a leaf. Therefore, the function of each lower level is best understood in the context of the system in which it exists. For this ...
We demonstrate the broad applicability of this approach through the de novo design of binding proteins to 12 diverse protein targets with different shapes and surface properties. Biophysical characterization shows that the binders, which are all smaller than 65 amino acids, are hyperstable and, ...
Furthermore, a multiproteome analysis has found that many highly aggregation prone stretches of amino acids in proteins are flanked by “gatekeeper” residues of lysine, arginine, or proline (Rousseau et al., 2006). These gatekeeper residues inhibit the formation of aggregates in these aggregation...
Each segment is assigned a feature vector based on properties of amino acids. These feature vectors from a set of proteins with known interface residues are used to train machine learning algorithms like random forest [13] or support vector machine [13,14,15,16,17,18,19]. The trained ...
anaerobic degradation of complex or high-molecular-weight organic compounds (e.g., polysaccharides and proteins) into smaller organic compounds (e.g., organic acids and amino acids)14. Another type are the ultimate consumers, which are responsible for the complete oxidation of organic compounds into...
of 35,000.Insulin, aproteinhormonepresent in thepancreasand responsible for regulation of blood-sugar levels, has a molecular unitderivedfrom 51amino acids(by themselves molecules containing carbon, hydrogen, oxygen, nitrogen, and sometimes sulfur). The exactmolecular weightof insulin from cattle has...
Keeping in view these previously reported inhibitors and their mode of action and the robust bindings and interactions of the compound 4h, which was able to interact directly with the important catalytic amino acids, i.e., the flap cysteine and other important histidine residues, and the direct ...