Bacterial type IV secretion systems (T4SSs) are largely responsible for the proliferation of multi-drug resistance. We solved the structure of the outer-membrane core complex (OMCCF) of a T4SS encoded by a conjugative F plasmid at <3.0 Å resolution by cryoelectron microscopy. The OMCCFco...
We continue to see variants with distinct predictions in a small region of a few amino acids. Close examination shows a strong association between mutation types and model predictions where deletion or insertion is more likely to be harmful than a single nucleotide variant. c, Further insights ...
(iii) Amino acids such as phenylalanine exist as zwitterions.Use the structure of phenylalanine to help explain how amino acids form zwitterions.Draw the structure of the zwitterion of phenylalanine.OH HaN phenylalanine(c)* The students wanted to confirm that the aspartame had been hydrolysed to pr...
These data allow a comparison of the sequence to that of alpha1-CB3 from calf and rat skin collagens. As compared with calf, the chick peptide contains 14 amino acid differences, whereas it contains 17 residue differences from the rat peptide. Thus, the sequence identity level is 91 and ...
Proteins are made up of polypeptide chains, which are amino acids joined together with peptide bonds. The unique sequence of amino acids that make up a protein or polypeptide chain is called the Primary Structure.Primary Structure: The unique sequence of amino acids that makes up a protein or ...
In Ace Lake, a stratified marine-derived system in the Vestfold Hills of East Antarctica, a Chlorobium species of green sulphur bacteria (GSB) is the dominant phototroph, although its seasonal abundance changes more than 100-fold. Here, we analysed 413 Gb of Antarctic metagenome data including...
The past few years have witnessed a veritable explosion in the development of new methods for the isolation and structure determination of natural products. This is true in particular for the applications of novel separation technologies and modern spect
l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a membrane flavoenzyme that catalyzes the deamination of neutral and aromatic l-amino acids into α-keto acids and ammonia. PmaLAAD does not use dioxygen to re-oxidize reduced FADH2 and thus does not produce hydrogen peroxide; ...
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Figure 3c shows the number of aligned amino acids per residue (Nr) and the pLDDT score along the protein sequence. Overall, the residue-level pLDDT scores show a strong correlation with Nr, demonstrating again the importance of MSA information in driving structure prediction. By contrast, DM...