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Since this landmark study, high-throughput electron-microscopic techniques have enabled reconstructions of much larger mammalian brain circuits at synaptic resolution2,3. Nevertheless, it remains unknown how the structure of a synapse relates to its physiological transmission strength—a key limitation for...
Synaptic transmission is the process whereby one neuron (nerve cell) communicates with other neurons or effectors , such as a muscle cell, at a synapse. A typical neuron has a cell body (soma), branching processes specialized to receive incoming signals (dendrites), and a single process (axon...
among all receptor bases; (2) clusters of fine horizontal cell dendrites penetrate the receptor base and terminate in a superficial spray of typical axodendritic synapses; (3) prominent bipolar dendrites enter within the horizontal cell processes terminating in the typical retinal ribbon synapse. The...
Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse ArticleOpen access03 September 2015 Main Synaptic neurotransmission involves the fusion of neurotransmitter-filled synaptic vesicles with the presynaptic plasma membrane upon Ca2+influx ...
We endeavored to harvest new data on the developmental appearance and spatiotemporal distribution of synapse-rich compartments in a specific cortical region, which can be used for future studies into functional, behavioral and molecular development of a normal cortex. In addition, these new multiscale...
The crystal structure of a novel Cre-Lox synapse complex reveals a symmetric protein trimer bound to a Y-shaped three-way DNA junction, a marked departure from the typical pseudo-4-fold symmetrical tetramer. The three-way DNA junction is accommodated by a simple kink of the adjoining DNA dupl...
Here we report a duplex device structure based on a ferroelectric field-effect transistor and an atomically thin MoS2 channel, and realize a universal in-memory computing architecture for in situ learning. By exploiting the tunability of the ferroelectric energy landscape, the duplex building block ...
C. Latrophilin GPCR signaling mediates synapse formation. eLife https://doi.org/10.7554/eLife.65717 (2021). Xiao, X. et al. A new understanding of GHSR1a—independent of ghrelin activation. Ageing Res Rev. 64, 101187 (2020). Article CAS PubMed Google Scholar Tao, Y. X. Constitutive ...
adhesion moleculeslike Slitrk and LAR-RPTPs and identified the regions of interaction through protein crystallography and transmission electron microscopy (TEM). Furthermore, they found that the formation of the synapse is induced after the combination of two synaptic adhesion molecules develops a ...