Structure and Function: Complementarity in the Phenomenon of LifeMacfarlane, Malcolm
Each domain can express a distinct function and is sometimes arranged in a single protein to efficiently carry out an overall function that has several parts. For example, there are seven different chemical reactions that act in sequence to synthesize a fatty acid. In mammals, the fatty acid ...
A disease-related example of enzymatic control of aggregation is the processing of the amyloid precursor protein (APP) by sequential cleavage reactions to yield Aβ. Because the “control” of Aβ formation does not have a known biological function, it may be better classified as an aberrant ...
2. The discovery of NEET proteins and their initial characterization 3. Cellular and whole organism function of NEET proteins 4. Outlook for the future of NEET protein research 5. Summary Acknowledgements ReferencesShow full outline Cited by (138) Figures (20) Show 14 more figuresBiochimica...
We demonstrate the utility of MI profile shifts in assessing the effects of mutations on protein stability, function, and disease phenotype. The importance of MI shifts, for the pyrin example the negative shifts, as indicators of severe functional effects is emphasized, along with exploring ...
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homology modeling is particularly well suited, because in general the overall sequence and structural similarity between antibodies is very high. In particular, the framework regions of antibodies are very well conserved, with most of the variability occurring in the complementarity-determining regions (...
In addition, while it is clear that ORC binds within chromatin, if and at which loci direct nucleosome interactions are required for its function is not well established. One example of such ambiguity corresponds to the protection of rDNA from genomic rearrangements. The borders of the rDNA are...
For electroproduc- tion, if F2D is the structure function of the deuterium D and F2A the structure function per nucleon of the nucleus A, the ratio RA = F2A(x, Q2)/F2D(x, Q2) is measured for various values of the Bjorken variable x and the squared momen- tum transferred Q2. ...
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