To address the sequence-function gap many computational methods have been developed with the goal to automatically predict protein function. Further, related work is directed at predicting function in a site- or domain-specific manner21,22,23,24. Traditional machine learning classifiers, such as supp...
To address the sequence-function gap many computational methods have been developed with the goal to automatically predict protein function. Further, related work is directed at predicting function in a site- or domain-specific manner21,22,23,24. Traditional machine learning classifiers, such as supp...
(2015c) "Structure-Based Function Prediction of Functionally Unannotated Structures in the PDB: Prediction of ATP, GTP, Sialic Acid, Retinoic Acid and Heme-bound and -Unbound (Free) Nitric Oxide Protein Binding Sites." [e-pub ahead of publication: arXiv.org/abs/1505.01143 [Quantitative Biology...
Identification of family-specific residue packing motifs and their use for structure-based protein function prediction: I. Method development Protein function prediction is one of the central problems in computational biology. We present a novel automated protein structure-based function predicti... D ...
I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function predictionXiaogen Zhou, Wei Zheng, Yang Li, Robin Pearce, Chengxin Zhang, Eric W. Bell, Guijun Zhang & Yang Zhang Nature Protocols volume 17, pages 2326–2353 (2022)Cite this article ...
Identification of Family-Specific Residue Packing Motifs and their use for Structure-Based Protein Function Prediction I. Method Development : ONLINE SUPPLEMENTARY MATERIAL Deepak Bandyopadhyay∗ Jun Huan† Jan Prins‡ Jack Snoeyink‡, Wei Wang‡ Alexander Tropsha§ March 26, 2009 Methodolo...
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Details the expansion of the computational protein structure prediction field Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts Includes supplementary material: sn.pub/extras Part of the book series: Methods in Molecular Biology (...
1、蛋白质的分子组成、结构与功能Structure and Function of Protein什么是蛋白质?蛋白质(protein)是由许多氨基酸(amino acids)通过肽键(peptide bond)相连形成的高分子含氮化合物。蛋白质研究的历史1833年,Payen和Persoz分离出淀粉酶。1838年,荷兰科学家 G. J. Mulder引入“protein”(源自希腊字proteios,意为primary...
verywell,thenthetargetproteinisassumedtohaveasimilarstructureas thetemplateandthestructureofthetargetcanbeconstructedbasedonthis alignment.Thegoodnessofonetarget-templatealignmentisevaluatedusing ascoringfunction.Proteinthreadingmakesastructurepredictionaccording ...