Achim Dickmanns and Ralf Ficner* Structure and function of spliceosomal DEAH-box ATPases https://doi.org/10.1515/hsz-2023-0157 Received March 10, 2023; accepted July 4, 2023; published online July 17, 2023 Abstract: Splicing of precursor mRNAs is a hallmark of eukaryotic cells, performed ...
Site-directed mutagenesis, deletion mutagenesis and construction of chimaeric proteins have all been used to characterize receptors. In this review, Walter Ward, David Timms and Alan Fersht describe the application of protein engineering, illustrating important concepts with experimental data. They explain...
2000. The structural similarity of the proteins extends to their function. All three proteins bind specifically to kink-turns (K-turns). The K-turn is an RNA motif that was identified in the structure of the 15.5 kDa protein bound to its cognate site in U4 snRNA (Vidovic et al., 2000)...
Yet, determining crystal structures of large macromolecular assemblies or membrane proteins that tend to diffract to lower resolutions is difficult and involves manually iterating over the different steps in the structure solution process1 and still may not lead to an interpretable electron density map....
(4) challenges this view by constructing a graph based on pair-wise structural relatedness judged by TM score of 5,906 proteins and showing that the average shortest … 展开 关键词: Proteins Protein Conformation DOI: 10.1073/pnas.0912339106 被引量: 2 ...
Capsular polysaccharides are important virulence factors in pathogenic bacteria. Characterizing the structural components and biosynthetic pathways for these polysaccharides is key to our ability to design vaccines and other preventative therapies that t
Protein structure, saccharides and fats Hi, Just need to clear up any misunderstanding about protein structure. Do all proteins have at least three levels of structure? If a protein has a quaternary structure, does it mean it also has primary, secondary and tertiary structures? I was wondering...
Theinaryoxin (Bin), producedy Lysinibacillusphaericus, isomposedfinA (42 kDa)ndinB (51 kDa) proteins, whichreothequiredorulloxicitygainstulexndnophelesosquito larvae.pecificityfinoxin is determinedyheindingfinBomponentoeceptor presentnheidgut epithelialembranes, whileinA is proposedoeoxicomponent....
Based on the primary structures of the DNA-binding and effector-binding domains, the CRP/FNR members have been classified into 21 subgroups (3). Up to now, the following eight proteins, representing seven subgroups, have been crystallized and structurally characterized: CRP (Protein Data Bank code...
Here, we review recent studies in the field that have advanced our knowledge of the structure and function of this expanding family of viral proteins. 1Biophysics Unit, University of the Basque Country and Spanish Science Research Council (CSIC), and Biochemistry Department, University of the ...