called RoseTTAFold diffusion (RFdiffusion), by experimentally characterizing the structures and functions of hundreds of designed symmetric assemblies, metal-binding proteins and protein binders. The accuracy of RFdiffusion is confirmed by the cryogenic electron microscopy structure of a designed binder in ...
•themostdiversifiedbiologicalfunctions Whatdoproteinsdointheorganism?Section1 MolecularCompositionofProteins Componentsofproteins •majorelementsC(50~55%),H(~7%),O(19~20%),N(13~19%),S(~4%)•traceelementsP,Fe,Cu,Zn,I,…•Theaveragenitrogencontentinproteinsisabout16%,andproteinsarethemajor...
Chapter1Protein1.Chemicalcomponents2.Molecularstructures3.Biologicalfunctions4.Structure-functionrelationship5.Physicalandchemicalproperties6..
C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The cry...
This reaction has been demonstrated to be intramolecular and to proceed with the formation of the intermediate phosphoform of the catalytic subunit. The data obtained on the structure of the regulatory subunit and its effect on the template activity of chromatin are discussed. In conclusion, a ...
peptidomimetic or small-molecule compounds has been explored as a therapeutic approach for MLL1-r leukemia. This review summarizes the biological functions, biochemistry, structure and inhibition of the critical PPIs involving MLL1 and its fusion partner proteins. In addition, challenges and perspectives...
Although the latter features are not among the most important ones in structure prediction, getting them right is both essential and difficult: essential because the fine-grained energy functions for high-resolution refinement depend on correct stereochemistry, and difficult because a simple energy ...
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function paradig
In conclusion, protein structure is a complex yet fascinating area of study (蛋白质结构是一个复杂而迷人的研究领域)。 Unraveling protein structure provides insights into biological functions and disease mechanisms (揭示蛋白质结构为了解生物学功能和疾病机制提供了线索)。©...
The scope of the upcoming special issue on ‘AlphaFold in protein structure and function prediction’ is focused on the studies that investigate and apply AlphaFold and its predictions in a variety of contexts including prediction of protein structure at the atomic, residue and protein levels, ...