AlphaFold and the release of AlphaFold predictions on the genomic scale via the AlphaFold DB have spurred a flurry of research across a broad spectrum of scales, from atomic-level studies of individual protein domains to protein-level investigations of protein functions and structures that span across...
called RoseTTAFold diffusion (RFdiffusion), by experimentally characterizing the structures and functions of hundreds of designed symmetric assemblies, metal-binding proteins and protein binders. The accuracy of RFdiffusion is confirmed by the cryogenic electron microscopy structure of a designed binder in ...
This reaction has been demonstrated to be intramolecular and to proceed with the formation of the intermediate phosphoform of the catalytic subunit. The data obtained on the structure of the regulatory subunit and its effect on the template activity of chromatin are discussed. In conclusion, a ...
•themostdiversifiedbiologicalfunctions Whatdoproteinsdointheorganism?Section1 MolecularCompositionofProteins Componentsofproteins •majorelementsC(50~55%),H(~7%),O(19~20%),N(13~19%),S(~4%)•traceelementsP,Fe,Cu,Zn,I,…•Theaveragenitrogencontentinproteinsisabout16%,andproteinsarethemajor...
Chapter1Protein1.Chemicalcomponents2.Molecularstructures3.Biologicalfunctions4.Structure-functionrelationship5.Physicalandchemicalproperties6..
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function paradig
structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local ...
peptidomimetic or small-molecule compounds has been explored as a therapeutic approach for MLL1-r leukemia. This review summarizes the biological functions, biochemistry, structure and inhibition of the critical PPIs involving MLL1 and its fusion partner proteins. In addition, challenges and perspectives...
C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The cry...
The design of proteins with desired functions is subtle and, as a result, combinatorial and directed evolution methods remain powerful approaches to protein engineering. Such combinatorial protein experiments will become more efficient when combined with computational algorithms, which can guide the design...